Publication: EVOO Promotes a Less Atherogenic Profile Than Sunflower Oil in Smooth Muscle Cells Through the Extracellular Vesicles Secreted by Endothelial Cells.
dc.contributor.author | Santiago-Fernandez, Concepcion | |
dc.contributor.author | Rodriguez-Diaz, Cristina | |
dc.contributor.author | Ho-Plagaro, Ailec | |
dc.contributor.author | Gutierrez-Repiso, Carolina | |
dc.contributor.author | Oliva-Olivera, Wilfredo | |
dc.contributor.author | Martin-Reyes, Flores | |
dc.contributor.author | Mela, Virginia | |
dc.contributor.author | Bautista, Rocio | |
dc.contributor.author | Tome, Monicas | |
dc.contributor.author | Gomez-Maldonado, Josefa | |
dc.contributor.author | Tinahones, Francisco J | |
dc.contributor.author | Garcia-Fuentes, Eduardo | |
dc.contributor.author | Garrido-Sanchez, Lourdes | |
dc.contributor.funder | Instituto de Salud Carlos III | |
dc.contributor.funder | Miguel Servet II Program | |
dc.contributor.funder | Nicolas Monardes program from the Consejería de Salud de Andalucía (Spain) | |
dc.contributor.funder | Consejeria de Salud de la Junta de Andalucía (Spain) | |
dc.date.accessioned | 2023-05-03T13:43:02Z | |
dc.date.available | 2023-05-03T13:43:02Z | |
dc.date.issued | 2022-04-12 | |
dc.description.abstract | Little is known about the effect of extra virgin olive (EVOO) and sunflower oil (SO) on the composition of extracellular vesicles (EVs) secreted by endothelial cells and the effects of these EVs on smooth muscle cells (SMCs). These cells play an important role in the development of atherosclerosis. We evaluated the effects of endothelial cells-derived EVs incubated with triglyceride-rich lipoproteins obtained after a high-fat meal with EVOO (EVOO-EVs) and SO (SO-EVs), on the transcriptomic profile of SMCs. We found 41 upregulated and 19 downregulated differentially expressed (DE)-miRNAs in EVOO-EVs. Afterwards, SMCs were incubated with EVOO-EVs and SO-EVs. SMCs incubated with SO-EVs showed a greater number of DE-mRNA involved in pathways related to cancer, focal adhesion, regulation of actin cytoskeleton, and MAPK, toll-like receptor, chemokine and Wnt signaling pathways than in SMCs incubated with EVOO-EVs. These DE-mRNAs were involved in biological processes related to the response to endogenous stimulus, cell motility, regulation of intracellular signal transduction and cell population proliferation. EVOO and SO can differently modify the miRNA composition of HUVEC-derived EVs. These EVs can regulate the SMCs transcriptomic profile, with SO-EVs promoting a profile more closely linked to the development of atherosclerosis than EVOO-EVs. | |
dc.description.version | Si | |
dc.identifier.citation | Santiago-Fernandez C, Rodríguez-Díaz C, Ho-Plagaro A, Gutierrez-Repiso C, Oliva-Olivera W, Martin-Reyes F, et al. EVOO Promotes a Less Atherogenic Profile Than Sunflower Oil in Smooth Muscle Cells Through the Extracellular Vesicles Secreted by Endothelial Cells. Front Nutr. 2022 Apr 12;9:867745 | |
dc.identifier.doi | 10.3389/fnut.2022.867745 | |
dc.identifier.issn | 2296-861X | |
dc.identifier.pmc | PMC9039400 | |
dc.identifier.pmid | 35495944 | |
dc.identifier.pubmedURL | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9039400/pdf | |
dc.identifier.unpaywallURL | https://www.frontiersin.org/articles/10.3389/fnut.2022.867745/pdf | |
dc.identifier.uri | http://hdl.handle.net/10668/20662 | |
dc.journal.title | Frontiers in nutrition | |
dc.journal.titleabbreviation | Front Nutr | |
dc.language.iso | en | |
dc.organization | Hospital Universitario Virgen de la Victoria | |
dc.organization | Hospital Universitario Regional de Málaga | |
dc.organization | Instituto de Investigación Biomédica de Málaga-IBIMA | |
dc.page.number | 12 | |
dc.provenance | Realizada la curación de contenido 01/04/2025 | |
dc.provenance | Realizada la curación de contenido 01/04/2025 | |
dc.publisher | Frontiers Research Foundation | |
dc.pubmedtype | Journal Article | |
dc.relation.projectID | PI14/01306 | |
dc.relation.projectID | CPII18/00030 | |
dc.relation.projectID | C-0028-2018 | |
dc.relation.projectID | CP20/00066 | |
dc.relation.projectID | PE-0098-2019 | |
dc.relation.publisherversion | https://doi.org/10.3389/fnut.2022.867745 | |
dc.rights | Attribution 4.0 International | |
dc.rights.accessRights | open access | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject | HUVECs | |
dc.subject | Extra-virgin olive oil | |
dc.subject | Extracellular vesicles (EVs) | |
dc.subject | miRNAs | |
dc.subject | Smooth muscle cells (SMCs) | |
dc.subject | Sunflower oil | |
dc.subject.decs | MicroARNs | |
dc.subject.decs | Células Endoteliales | |
dc.subject.decs | Aterosclerosis | |
dc.subject.decs | Movimiento Celular | |
dc.subject.decs | Vesículas Extracelulares | |
dc.subject.decs | Transducción de Señal | |
dc.subject.mesh | Endothelial Cells | |
dc.subject.mesh | RNA, Messenger | |
dc.subject.mesh | Extracellular Vesicles | |
dc.subject.mesh | Actin Cytoskeleton | |
dc.subject.mesh | Cell Movement | |
dc.subject.mesh | Toll-Like Receptors | |
dc.title | EVOO Promotes a Less Atherogenic Profile Than Sunflower Oil in Smooth Muscle Cells Through the Extracellular Vesicles Secreted by Endothelial Cells. | |
dc.type | research article | |
dc.type.hasVersion | VoR | |
dc.volume.number | 9 | |
dspace.entity.type | Publication |