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EVOO Promotes a Less Atherogenic Profile Than Sunflower Oil in Smooth Muscle Cells Through the Extracellular Vesicles Secreted by Endothelial Cells.

dc.contributor.authorSantiago-Fernandez, Concepcion
dc.contributor.authorRodriguez-Diaz, Cristina
dc.contributor.authorHo-Plagaro, Ailec
dc.contributor.authorGutierrez-Repiso, Carolina
dc.contributor.authorOliva-Olivera, Wilfredo
dc.contributor.authorMartin-Reyes, Flores
dc.contributor.authorMela, Virginia
dc.contributor.authorBautista, Rocio
dc.contributor.authorTome, Monicas
dc.contributor.authorGomez-Maldonado, Josefa
dc.contributor.authorTinahones, Francisco J
dc.contributor.authorGarcia-Fuentes, Eduardo
dc.contributor.authorGarrido-Sanchez, Lourdes
dc.contributor.funderInstituto de Salud Carlos III
dc.contributor.funderMiguel Servet II Program
dc.contributor.funderNicolas Monardes program from the Consejería de Salud de Andalucía (Spain)
dc.contributor.funderConsejeria de Salud de la Junta de Andalucía (Spain)
dc.date.accessioned2023-05-03T13:43:02Z
dc.date.available2023-05-03T13:43:02Z
dc.date.issued2022-04-12
dc.description.abstractLittle is known about the effect of extra virgin olive (EVOO) and sunflower oil (SO) on the composition of extracellular vesicles (EVs) secreted by endothelial cells and the effects of these EVs on smooth muscle cells (SMCs). These cells play an important role in the development of atherosclerosis. We evaluated the effects of endothelial cells-derived EVs incubated with triglyceride-rich lipoproteins obtained after a high-fat meal with EVOO (EVOO-EVs) and SO (SO-EVs), on the transcriptomic profile of SMCs. We found 41 upregulated and 19 downregulated differentially expressed (DE)-miRNAs in EVOO-EVs. Afterwards, SMCs were incubated with EVOO-EVs and SO-EVs. SMCs incubated with SO-EVs showed a greater number of DE-mRNA involved in pathways related to cancer, focal adhesion, regulation of actin cytoskeleton, and MAPK, toll-like receptor, chemokine and Wnt signaling pathways than in SMCs incubated with EVOO-EVs. These DE-mRNAs were involved in biological processes related to the response to endogenous stimulus, cell motility, regulation of intracellular signal transduction and cell population proliferation. EVOO and SO can differently modify the miRNA composition of HUVEC-derived EVs. These EVs can regulate the SMCs transcriptomic profile, with SO-EVs promoting a profile more closely linked to the development of atherosclerosis than EVOO-EVs.
dc.description.versionSi
dc.identifier.citationSantiago-Fernandez C, Rodríguez-Díaz C, Ho-Plagaro A, Gutierrez-Repiso C, Oliva-Olivera W, Martin-Reyes F, et al. EVOO Promotes a Less Atherogenic Profile Than Sunflower Oil in Smooth Muscle Cells Through the Extracellular Vesicles Secreted by Endothelial Cells. Front Nutr. 2022 Apr 12;9:867745
dc.identifier.doi10.3389/fnut.2022.867745
dc.identifier.issn2296-861X
dc.identifier.pmcPMC9039400
dc.identifier.pmid35495944
dc.identifier.pubmedURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9039400/pdf
dc.identifier.unpaywallURLhttps://www.frontiersin.org/articles/10.3389/fnut.2022.867745/pdf
dc.identifier.urihttp://hdl.handle.net/10668/20662
dc.journal.titleFrontiers in nutrition
dc.journal.titleabbreviationFront Nutr
dc.language.isoen
dc.organizationHospital Universitario Virgen de la Victoria
dc.organizationHospital Universitario Regional de Málaga
dc.organizationInstituto de Investigación Biomédica de Málaga-IBIMA
dc.page.number12
dc.provenanceRealizada la curación de contenido 01/04/2025
dc.provenanceRealizada la curación de contenido 01/04/2025
dc.publisherFrontiers Research Foundation
dc.pubmedtypeJournal Article
dc.relation.projectIDPI14/01306
dc.relation.projectIDCPII18/00030
dc.relation.projectIDC-0028-2018
dc.relation.projectIDCP20/00066
dc.relation.projectIDPE-0098-2019
dc.relation.publisherversionhttps://doi.org/10.3389/fnut.2022.867745
dc.rightsAttribution 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectHUVECs
dc.subjectExtra-virgin olive oil
dc.subjectExtracellular vesicles (EVs)
dc.subjectmiRNAs
dc.subjectSmooth muscle cells (SMCs)
dc.subjectSunflower oil
dc.subject.decsMicroARNs
dc.subject.decsCélulas Endoteliales
dc.subject.decsAterosclerosis
dc.subject.decsMovimiento Celular
dc.subject.decsVesículas Extracelulares
dc.subject.decsTransducción de Señal
dc.subject.meshEndothelial Cells
dc.subject.meshRNA, Messenger
dc.subject.meshExtracellular Vesicles
dc.subject.meshActin Cytoskeleton
dc.subject.meshCell Movement
dc.subject.meshToll-Like Receptors
dc.titleEVOO Promotes a Less Atherogenic Profile Than Sunflower Oil in Smooth Muscle Cells Through the Extracellular Vesicles Secreted by Endothelial Cells.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number9
dspace.entity.typePublication

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