Publication:
STIM and Orail Variants in Store-Operated Calcium Entry

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Date

2016-01-13

Authors

Rosado, Juan A.
Diez, Raquel
Smani, Tarik
Jardin, Isaac

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Frontiers media sa
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Abstract

Store-operated Ca2+ entry (SOCE) is an ubiquitous mechanism for Ca2+ entry in eukaryotic cells. This route for Ca2+ influx is regulated by the filling state of the intracellular Ca2+ stores communicated to the plasma membrane channels by the proteins of the Stromal Interaction Molecule (STIM) family, STIM1, and STIM2. Store-dependent, STIM1-modulated, channels include the Ca2+ release-activated Ca2+ channels, comprised of subunits of Orai proteins, as well as the store-operated Ca2+ (SOC) channels, involving Orai1, and members of the canonical transient receptor potential family of proteins. Recent studies have revealed the expression of splice variants of STIM1, STIM2, and Orai1 in different cell types. While certain variants are ubiquitously expressed, others, such as STIM1L, show a more restricted expression. The splice variants for STIM and Orai1 proteins exhibit significant functional differences and reveal that alternative splicing enhance the functional diversity of STIM1, STIM2, and Orai1 genes to modulate the dynamics of Ca2+ signals.

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MeSH Terms

calcium entry
splice variants
Activates crac channels
Mechanistic insights
C-terminus

DeCS Terms

Molécula de interacción estromal 1
Proteína ORAI1
Inmunohistoquímica
Empalme alternativo
Proteínas
Células eucariotas
Parvalbúminas

CIE Terms

Keywords

STIM1, STIM2, orail, Stromal interaction molecule-1, Alternative translation initiation, Ca2+ entry, Trpc channels, Arc channel, Sam domain, I-crac

Citation

Rosado JA, Diez R, Smani T, Jardín I. STIM and Orai1 Variants in Store-Operated Calcium Entry. Front Pharmacol. 2016 Jan 13;6:325.