Please use this identifier to cite or link to this item:
Title: Hepatic insulin resistance both in prediabetic and diabetic patients determines postprandial lipoprotein metabolism: from the CORDIOPREV study.
Authors: Leon-Acuña, A
Alcala-Diaz, J F
Delgado-Lista, J
Torres-Peña, J D
Lopez-Moreno, J
Camargo, A
Garcia-Rios, A
Marin, C
Gomez-Delgado, F
Caballero, J
Van-Ommen, B
Malagon, M M
Perez-Martinez, P
Lopez-Miranda, J
Keywords: CORDIOPREV study;Insulin resistance;Phenotypic flexibility;Postprandial lipemia;Prediabetic;Triglycerides
metadata.dc.subject.mesh: Adult
Aged, 80 and over
Blood Glucose
Diabetes Mellitus, Type 2
Insulin Resistance
Middle Aged
Postprandial Period
Prediabetic State
Risk Factors
Issue Date: 19-Apr-2016
Abstract: Previous evidences have shown the presence of a prolonged and exaggerated postprandial response in type 2 diabetes mellitus (T2DM) and its relation with an increase of cardiovascular risk. However, the response in prediabetes population has not been established. The objective was to analyze the degree of postprandial lipemia response in the CORDIOPREV clinical trial (NCT00924937) according to the diabetic status. 1002 patients were submitted to an oral fat load test meal (OFTT) with 0.7 g fat/kg body weight [12 % saturated fatty acids (SFA), 10 % polyunsaturated fatty acids (PUFA), 43 % monounsaturated fatty acids (MUFA), 10 % protein and 25 % carbohydrates]. Serial blood test analyzing lipid fractions were drawn at 0, 1, 2, 3 and 4 h during postprandial state. Postprandial triglycerides (TG) concentration at any point >2.5 mmol/L (220 mg/dL) has been established as undesirable response. We explored the dynamic response in 57 non-diabetic, 364 prediabetic and 581 type 2 diabetic patients. Additionally, the postprandial response was evaluated according to basal insulin resistance subgroups in patients non-diabetic and diabetic without pharmacological treatment (N = 642). Prevalence of undesirable postprandial TG was 35 % in non-diabetic, 48 % in prediabetic and 59 % in diabetic subgroup, respectively (p Our findings demonstrate that prediabetic patients show a lower phenotypic flexibility after external aggression, such as OFTT compared with nondiabetic patients. The postprandial response increases progressively according to non-diabetic, prediabetic and type 2 diabetic state and it is higher in patients with liver insulin-resistance. To identify this subgroup of patients is important to treat more intensively in order to avoid future cardiometabolic complications.
metadata.dc.identifier.doi: 10.1186/s12933-016-0380-y
Appears in Collections:Producción 2020

Files in This Item:
File SizeFormat 
PMC4837552.pdf1,29 MBAdobe PDFView/Open

This item is protected by original copyright

This item is licensed under a Creative Commons License Creative Commons