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Title: A prognostic model for survival after salvage treatment with FLAG-Ida +/- gemtuzumab-ozogamicine in adult patients with refractory/relapsed acute myeloid leukaemia.
Authors: Bergua, Juan M
Montesinos, Pau
Martinez-Cuadrón, David
Fernández-Abellán, Pascual
Serrano, Josefina
Sayas, María J
Prieto-Fernandez, Julio
García, Raimundo
García-Huerta, Ana J
Barrios, Manuel
Benavente, Celina
Pérez-Encinas, Manuel
Simiele, Adriana
Rodríguez-Macias, Gabriela
Herrera-Puente, Pilar
Rodríguez-Veiga, Rebeca
Martínez-Sánchez, María P
Amador-Barciela, María L
Riaza-Grau, Rosalía
Sanz, Miguel A
Keywords: FLAG-Ida;genetic risk;prognostic factors;relapsed-refractory acute myeloid leukaemia;salvage treatment
metadata.dc.subject.mesh: Adolescent
Antibodies, Monoclonal, Humanized
Antineoplastic Combined Chemotherapy Protocols
Granulocyte Colony-Stimulating Factor
Hematopoietic Stem Cell Transplantation
Leukemia, Myeloid, Acute
Middle Aged
Remission Induction
Retrospective Studies
Risk Assessment
Salvage Therapy
Survival Analysis
Young Adult
Issue Date: 26-Apr-2016
Abstract: The combination of fludarabine, cytarabine, idarubicin, and granulocyte colony-stimulating factor (FLAG-Ida) is widely used in relapsed/refractory acute myeloid leukaemia (AML). We retrospectively analysed the results of 259 adult AML patients treated as first salvage with FLAG-Ida or FLAG-Ida plus Gentuzumab-Ozogamicin (FLAGO-Ida) of the Programa Español de Tratamientos en Hematología (PETHEMA) database, developing a prognostic score system of survival in this setting (SALFLAGE score). Overall, 221 patients received FLAG-Ida and 38 FLAGO-Ida; 92 were older than 60 years. The complete remission (CR)/CR with incomplete blood count recovery (CRi) rate was 51%, with 9% of induction deaths. Three covariates were associated with lower CR/CRi: high-risk cytogenetics and t(8;21) at diagnosis, no previous allogeneic stem cell transplantation (allo-SCT) and relapse-free interval
metadata.dc.identifier.doi: 10.1111/bjh.14107
Appears in Collections:Producción 2020

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