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Title: Minimal residual disease monitoring and immune profiling in multiple myeloma in elderly patients.
Authors: Paiva, Bruno
Cedena, Maria-Teresa
Puig, Noemi
Arana, Paula
Vidriales, Maria-Belen
Cordon, Lourdes
Flores-Montero, Juan
Gutierrez, Norma C
Martín-Ramos, María-Luisa
Martinez-Lopez, Joaquin
Ocio, Enrique M
Hernandez, Miguel T
Teruel, Ana-Isabel
Rosiñol, Laura
Echeveste, María-Asunción
Martinez, Rafael
Gironella, Mercedes
Oriol, Albert
Cabrera, Carmen
Martin, Jesus
Bargay, Joan
Encinas, Cristina
Gonzalez, Yolanda
Van Dongen, Jacques J M
Orfao, Alberto
Bladé, Joan
Mateos, Maria-Victoria
Lahuerta, Juan José
San Miguel, Jesús F
Grupo Español de Mieloma/Programa para el Estudio de la Terapéutica en Hemopatías Malignas (GEM/PETHEMA) Cooperative Study Groups
metadata.dc.subject.mesh: Aged
Aged, 80 and over
Antineoplastic Combined Chemotherapy Protocols
Biomarkers, Pharmacological
Biomarkers, Tumor
Drug Monitoring
Monitoring, Physiologic
Multiple Myeloma
Neoplasm, Residual
Survival Analysis
Issue Date: 26-Apr-2016
Abstract: The value of minimal residual disease (MRD) in multiple myeloma (MM) has been more frequently investigated in transplant-eligible patients than in elderly patients. Because an optimal balance between treatment efficacy and toxicity is of utmost importance in patients with elderly MM, sensitive MRD monitoring might be particularly valuable in this patient population. Here, we used second-generation 8-color multiparameter-flow cytometry (MFC) to monitor MRD in 162 transplant-ineligible MM patients enrolled in the PETHEMA/GEM2010MAS65 study. The transition from first- to second-generation MFC resulted in increased sensitivity and allowed us to identify 3 patient groups according to MRD levels: MRD negative (75 years (HR, 4.8; P
metadata.dc.identifier.doi: 10.1182/blood-2016-03-705319
Appears in Collections:Producción 2020

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