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http://hdl.handle.net/10668/10030| Title: | Minimal residual disease monitoring and immune profiling in multiple myeloma in elderly patients. |
| Authors: | Paiva, Bruno Cedena, Maria-Teresa Puig, Noemi Arana, Paula Vidriales, Maria-Belen Cordon, Lourdes Flores-Montero, Juan Gutierrez, Norma C Martín-Ramos, María-Luisa Martinez-Lopez, Joaquin Ocio, Enrique M Hernandez, Miguel T Teruel, Ana-Isabel Rosiñol, Laura Echeveste, María-Asunción Martinez, Rafael Gironella, Mercedes Oriol, Albert Cabrera, Carmen Martin, Jesus Bargay, Joan Encinas, Cristina Gonzalez, Yolanda Van Dongen, Jacques J M Orfao, Alberto Bladé, Joan Mateos, Maria-Victoria Lahuerta, Juan José San Miguel, Jesús F Grupo Español de Mieloma/Programa para el Estudio de la Terapéutica en Hemopatías Malignas (GEM/PETHEMA) Cooperative Study Groups |
| metadata.dc.subject.mesh: | Aged Aged, 80 and over Antineoplastic Combined Chemotherapy Protocols Biomarkers, Pharmacological Biomarkers, Tumor Dexamethasone Drug Monitoring Female Humans Immunity Lenalidomide Male Melphalan Monitoring, Physiologic Multiple Myeloma Neoplasm, Residual Prednisone Prognosis Survival Analysis Thalidomide Vincristine |
| Issue Date: | 26-Apr-2016 |
| Abstract: | The value of minimal residual disease (MRD) in multiple myeloma (MM) has been more frequently investigated in transplant-eligible patients than in elderly patients. Because an optimal balance between treatment efficacy and toxicity is of utmost importance in patients with elderly MM, sensitive MRD monitoring might be particularly valuable in this patient population. Here, we used second-generation 8-color multiparameter-flow cytometry (MFC) to monitor MRD in 162 transplant-ineligible MM patients enrolled in the PETHEMA/GEM2010MAS65 study. The transition from first- to second-generation MFC resulted in increased sensitivity and allowed us to identify 3 patient groups according to MRD levels: MRD negative (75 years (HR, 4.8; P |
| URI: | http://hdl.handle.net/10668/10030 |
| metadata.dc.identifier.doi: | 10.1182/blood-2016-03-705319 |
| Appears in Collections: | Producción 2020 |
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