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Title: Molecular modulators of store-operated calcium entry.
Authors: Lopez, Jose J
Albarran, Letizia
Gómez, Luis J
Smani, Tarik
Salido, Gines M
Rosado, Juan A
Keywords: CRACR2A;Golli;ORMDL3;Orai1;SARAF;STIM1;Septin;Store-operated calcium entry
metadata.dc.subject.mesh: Animals
Calcium Channels
Calcium Release Activated Calcium Channels
Calcium Signaling
Endoplasmic Reticulum
Intracellular Calcium-Sensing Proteins
Membrane Proteins
Models, Biological
ORAI1 Protein
Protein Conformation
Protein Subunits
Stromal Interaction Molecule 1
TRPC Cation Channels
Issue Date: 27-Apr-2016
Abstract: Three decades ago, store-operated Ca(2+) entry (SOCE) was identified as a unique mechanism for Ca(2+) entry through plasma membrane (PM) Ca(2+)-permeable channels modulated by the intracellular Ca(2+) stores, mainly the endoplasmic reticulum (ER). Extensive analysis of the communication between the ER and the PM leads to the identification of the protein STIM1 as the ER-Ca(2+) sensor that gates the Ca(2+) channels in the PM. Further analysis on the biophysical, electrophysiological and biochemical properties of STIM1-dependent Ca(2+) channels has revealed the presence of a highly Ca(2+)-selective channel termed Ca(2+) release-activated Ca(2+) channel (CRAC), consisting of Orai1 subunits, and non-selective cation channels named store-operated channels (SOC), including both Orai1 and TRPC channel subunits. Since the identification of the key elements of CRAC and SOC channels a number of intracellular modulators have been reported to play essential roles in the stabilization of STIM-Orai interactions, collaboration with STIM1 conformational changes or mediating slow Ca(2+)-dependent inactivation. Here, we review our current understanding of some of the key modulators of STIM1-Orai1 interaction, including the proteins CRACR2A, STIMATE, SARAF, septins, golli and ORMDL3.
metadata.dc.identifier.doi: 10.1016/j.bbamcr.2016.04.024
ISSN: 0006-3002
Appears in Collections:Producción 2020

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