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Title: Occupational Exposure to Endocrine-Disrupting Chemicals and Birth Weight and Length of Gestation: A European Meta-Analysis.
Authors: Birks, Laura
Casas, Maribel
Garcia, Ana M
Alexander, Jan
Barros, Henrique
Bergström, Anna
Bonde, Jens Peter
Burdorf, Alex
Costet, Nathalie
Danileviciute, Asta
Eggesbø, Merete
Fernández, Mariana F
González-Galarzo, M Carmen
Regina Gražulevičienė
Hanke, Wojciech
Jaddoe, Vincent
Kogevinas, Manolis
Kull, Inger
Lertxundi, Aitana
Melaki, Vasiliki
Andersen, Anne-Marie Nybo
Olea, Nicolás
Polanska, Kinga
Rusconi, Franca
Santa-Marina, Loreto
Santos, Ana Cristina
Vrijkotte, Tanja
Zugna, Daniela
Nieuwenhuijsen, Mark
Cordier, Sylvaine
Vrijheid, Martine
metadata.dc.subject.mesh: Birth Weight
Endocrine Disruptors
Gestational Age
Infant, Low Birth Weight
Infant, Newborn
Maternal Exposure
Occupational Exposure
Issue Date: 6-May-2016
Abstract: Women of reproductive age can be exposed to endocrine-disrupting chemicals (EDCs) at work, and exposure to EDCs in pregnancy may affect fetal growth. We assessed whether maternal occupational exposure to EDCs during pregnancy as classified by application of a job exposure matrix was associated with birth weight, term low birth weight (LBW), length of gestation, and preterm delivery. Using individual participant data from 133,957 mother-child pairs in 13 European cohorts spanning births from 1994 through 2011, we linked maternal job titles with exposure to 10 EDC groups as assessed through a job exposure matrix. For each group, we combined the two levels of exposure categories (possible and probable) and compared birth outcomes with the unexposed group (exposure unlikely). We performed meta-analyses of cohort-specific estimates. Eleven percent of pregnant women were classified as exposed to EDCs at work during pregnancy, based on job title. Classification of exposure to one or more EDC group was associated with an increased risk of term LBW [odds ratio (OR) = 1.25; 95% CI: 1.04, 1.49], as were most specific EDC groups; this association was consistent across cohorts. Further, the risk increased with increasing number of EDC groups (OR = 2.11; 95% CI: 1.10, 4.06 for exposure to four or more EDC groups). There were few associations (p Results from our large population-based birth cohort design indicate that employment during pregnancy in occupations classified as possibly or probably exposed to EDCs was associated with an increased risk of term LBW. Citation: Birks L, Casas M, Garcia AM, Alexander J, Barros H, Bergström A, Bonde JP, Burdorf A, Costet N, Danileviciute A, Eggesbø M, Fernández MF, González-Galarzo MC, Gražulevičienė R, Hanke W, Jaddoe V, Kogevinas M, Kull I, Lertxundi A, Melaki V, Andersen AM, Olea N, Polanska K, Rusconi F, Santa-Marina L, Santos AC, Vrijkotte T, Zugna D, Nieuwenhuijsen M, Cordier S, Vrijheid M. 2016. Occupational exposure to endocrine-disrupting chemicals and birth weight and length of gestation: a European meta-analysis. Environ Health Perspect 124:1785-1793;
metadata.dc.identifier.doi: 10.1289/EHP208
Appears in Collections:Producción 2020

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