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Title: Busulfan-based reduced intensity conditioning regimens for haploidentical transplantation in relapsed/refractory Hodgkin lymphoma: Spanish multicenter experience.
Authors: Gayoso, J
Balsalobre, P
Pascual, M J
Castilla-Llorente, C
López-Corral, L
Kwon, M
Serrano, D
Piñana, J L
Herrera, P
Ferrá, C
Pascual, C
Heras, I
Montesinos, P
Zabalza, A
Bento, L
Figuera, A
Buño, I
Díez-Martín, J L
metadata.dc.subject.mesh: Adolescent
Graft vs Host Disease
Hodgkin Disease
Middle Aged
Salvage Therapy
Survival Analysis
Transplantation Conditioning
Transplantation, Haploidentical
Young Adult
Issue Date: 9-May-2016
Abstract: Relapsed or refractory Hodgkin lymphoma (advanced HL) still remains a therapeutic challenge. Recently, unmanipulated haploidentical related donor transplant with reduced conditioning regimen (HAPLO-RIC) and post-transplant cyclophosphamide (PT-Cy) as GvHD prophylaxis has became a promising rescue strategy potentially available to almost every patient. This paper reports our multicenter experience using an IV busulfan-based HAPLO-RIC regimen and PT-Cy in the treatment of 43 patients with advanced HL. Engraftment occurred in 42 patients (97.5%), with a median time to neutrophil and platelet recovery of 18 and 26 days. Cumulative incidences of grades II-IV acute GvHD and chronic GvHD were 39% and 19%, respectively. With a median follow-up of 25.5 months for survivors, 27 patients are alive, with 22 of them disease free. Cumulative incidences of 1-year non-relapse mortality and relapse at 2 years were 21% and 24%, respectively. The estimated 2-year event-free survival (EFS) and overall survival (OS) were 48% and 58%, respectively. CR prior to HAPLO-RIC correlated with better EFS (78.5% vs 33.5%; P=0.015) and OS (86% vs 46%; P=0.044). Our findings further confirm prior reports using HAPLO-RIC in advanced HL in a multicenter approach employing an IV busulfan-based conditioning regimen.
metadata.dc.identifier.doi: 10.1038/bmt.2016.115
Appears in Collections:Producción 2020

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