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Institutional Health Repository of Andalucía
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http://hdl.handle.net/10668/10140| Title: | Impact of the PROVAUR stewardship programme on linezolid resistance in a tertiary university hospital: a before-and-after interventional study. |
| Authors: | García-Martínez, Lucrecia Gracia-Ahulfinger, Irene Machuca, Isabel Cantisán, Sara De La Fuente, Soraya Natera, Clara Pérez-Nadales, Elena Vidal, Elisa Rivero, Antonio Rodríguez-Lopez, Fernando Del Prado, José Ramón Torre-Cisneros, Julián |
| metadata.dc.subject.mesh: | Anti-Bacterial Agents Attitude of Health Personnel Behavior Therapy Drug Resistance, Bacterial Drug Utilization Education, Medical, Continuing Enterococcus faecalis Gram-Positive Bacterial Infections Health Policy Hospitals, University Humans Linezolid Non-Randomized Controlled Trials as Topic Retrospective Studies Staphylococcus Surveys and Questionnaires Tertiary Care Centers |
| Issue Date: | 30-May-2016 |
| Abstract: | There is little evidence of the impact of antimicrobial stewardship programmes on antimicrobial resistance. To study the efficacy and safety of a package of educational and interventional measures to optimize linezolid use and its impact on bacterial resistance. A quasi-experimental study was designed and carried out before and after implementation of a stewardship programme in hospitalized patients with Gram-positive infections treated with linezolid. The intervention reduced linezolid consumption by 76%. The risk of linezolid-resistant CoNS isolates (OR = 0.37; 95% CI = 0.27-0.49; P A programme to optimize linezolid use can contribute to reducing the resistance rate of CoNS and E. faecalis to this antibiotic. |
| URI: | http://hdl.handle.net/10668/10140 |
| metadata.dc.identifier.doi: | 10.1093/jac/dkw179 |
| Appears in Collections: | Producción 2020 |
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