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Title: Impact of the PROVAUR stewardship programme on linezolid resistance in a tertiary university hospital: a before-and-after interventional study.
Authors: García-Martínez, Lucrecia
Gracia-Ahulfinger, Irene
Machuca, Isabel
Cantisán, Sara
De La Fuente, Soraya
Natera, Clara
Pérez-Nadales, Elena
Vidal, Elisa
Rivero, Antonio
Rodríguez-Lopez, Fernando
Del Prado, José Ramón
Torre-Cisneros, Julián
metadata.dc.subject.mesh: Anti-Bacterial Agents
Attitude of Health Personnel
Behavior Therapy
Drug Resistance, Bacterial
Drug Utilization
Education, Medical, Continuing
Enterococcus faecalis
Gram-Positive Bacterial Infections
Health Policy
Hospitals, University
Non-Randomized Controlled Trials as Topic
Retrospective Studies
Surveys and Questionnaires
Tertiary Care Centers
Issue Date: 30-May-2016
Abstract: There is little evidence of the impact of antimicrobial stewardship programmes on antimicrobial resistance. To study the efficacy and safety of a package of educational and interventional measures to optimize linezolid use and its impact on bacterial resistance. A quasi-experimental study was designed and carried out before and after implementation of a stewardship programme in hospitalized patients with Gram-positive infections treated with linezolid. The intervention reduced linezolid consumption by 76%. The risk of linezolid-resistant CoNS isolates (OR = 0.37; 95% CI = 0.27-0.49; P  A programme to optimize linezolid use can contribute to reducing the resistance rate of CoNS and E. faecalis to this antibiotic.
metadata.dc.identifier.doi: 10.1093/jac/dkw179
Appears in Collections:Producción 2020

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