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Title: Modifiable causes of premature death in middle-age in Western Europe: results from the EPIC cohort study.
Authors: Muller, David C
Murphy, Neil
Johansson, Mattias
Ferrari, Pietro
Tsilidis, Konstantinos K
Boutron-Ruault, Marie-Christine
Clavel, Francoise
Dartois, Laureen
Li, Kuanrong
Kaaks, Rudolf
Weikert, Cornelia
Bergmann, Manuela
Boeing, Heiner
Tjønneland, Anne
Overvad, Kim
Redondo, M Luisa
Agudo, Antonio
Molina-Portillo, Elena
Altzibar, Jone M
Cirera, Lluís
Ardanaz, Eva
Khaw, Kay-Tee
Wareham, Nicholas J
Key, Timothy J
Travis, Ruth C
Bamia, Christina
Orfanos, Philippos
Trichopoulou, Antonia
Palli, Domenico
Pala, Valeria
Tumino, Rosario
Vineis, Paolo
Panico, Salvatore
Bueno-de-Mesquita, H Bas
Verschuren, W M Monique
Struijk, Ellen A
Peeters, Petra H
Engström, Gunnar
Melander, Olle
Sund, Malin
Weiderpass, Elisabete
Skeie, Guri
Lund, Eiliv
Norat, Teresa
Gunter, Marc
Riboli, Elio
Brennan, Paul
Keywords: Absolute risk;Attributable fraction;Modifiable risk factors;Mortality;Premature death
metadata.dc.subject.mesh: Adult
Alcohol Drinking
Cohort Studies
Life Expectancy
Middle Aged
Mortality, Premature
Motor Activity
Prospective Studies
Risk Factors
Issue Date: 14-Jun-2016
Abstract: Life expectancy is increasing in Europe, yet a substantial proportion of adults still die prematurely before the age of 70 years. We sought to estimate the joint and relative contributions of tobacco smoking, hypertension, obesity, physical inactivity, alcohol and poor diet towards risk of premature death. We analysed data from 264,906 European adults from the EPIC prospective cohort study, aged between 40 and 70 years at the time of recruitment. Flexible parametric survival models were used to model risk of death conditional on risk factors, and survival functions and attributable fractions (AF) for deaths prior to age 70 years were calculated based on the fitted models. We identified 11,930 deaths which occurred before the age of 70. The AF for premature mortality for smoking was 31 % (95 % confidence interval (CI), 31-32 %) and 14 % (95 % CI, 12-16 %) for poor diet. Important contributions were also observed for overweight and obesity measured by waist-hip ratio (10 %; 95 % CI, 8-12 %) and high blood pressure (9 %; 95 % CI, 7-11 %). AFs for physical inactivity and excessive alcohol intake were 7 % and 4 %, respectively. Collectively, the AF for all six risk factors was 57 % (95 % CI, 55-59 %), being 35 % (95 % CI, 32-37 %) among never smokers and 74 % (95 % CI, 73-75 %) among current smokers. While smoking remains the predominant risk factor for premature death in Europe, poor diet, overweight and obesity, hypertension, physical inactivity, and excessive alcohol consumption also contribute substantially. Any attempt to minimise premature deaths will ultimately require all six factors to be addressed.
metadata.dc.identifier.doi: 10.1186/s12916-016-0630-6
Appears in Collections:Producción 2020

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