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dc.contributor.authorLópez-García, Alejandro
dc.contributor.authorSoto-Navarrete, M Teresa
dc.contributor.authorFernández, M Carmen
dc.contributor.authorMoncayo-Arlandi, Javier
dc.contributor.authorDurán, Ana Carmen
dc.contributor.authorLópez-Unzu, Miguel A
dc.contributor.authorAlonso-Briales, Juan Horacio
dc.contributor.authorFernández, Borja
dc.description.abstractA previous manuscript [Fernández B, et al. (2008) J Anat 212, 12] reported on the unusual coronary artery patterns in mice belonging to the C57BL/6 strain. The aim here was to elucidate whether this pattern is unique to C57BL/6 mice or appears in other laboratory mouse strains and in wild-living mice. Stereomicroscopy, scanning electron microscopy, light microscopy and a corrosion cast technique were used to examine 597 adult mice belonging to three inbred strains (C57BL/6, Balb/c, DBA/2), three outbred stocks (CD1, OF1, NMRI) two hybrid lines (129sv × BL/6, CD2F1) and wild mice. It was shown that lock-like ostium is an exclusive trait of C57BL/6 mice, whereas left septal artery, accessory ostium, high take-off, intramural course and solitary ostium in aorta are all present in the different laboratory strains and wild mice included in the present study. However, each mouse population shows a specific incidence of these coronary conditions. Several clinically relevant human coronary artery anomalies are present in healthy mice from different strains that may serve as animal models for humans. These results should be taken into consideration in research concerning the murine coronary system, especially in coronary artery occlusion experiments and in studies on cardiovascular developmental biology using murine mutant lines.
dc.subjectcoronary arteries
dc.subjectgenetic background
dc.subject.meshCoronary Vessels
dc.subject.meshMice, Inbred C57BL
dc.subject.meshMice, Inbred Strains
dc.titleUnusual anatomical origins of the coronary arteries in C57BL/6 mice. Are they strain-specific?
dc.typeresearch article
dc.rights.accessRightsopen access
dc.journal.titleJournal of anatomy
dc.journal.titleabbreviationJ Anat
dc.organizationInstituto de Investigación Biomédica de Málaga-IBIMA
dc.organizationHospital Universitario Virgen de la Victoria
dc.pubmedtypeJournal Article
dc.pubmedtypeResearch Support, Non-U.S. Gov't
Appears in Collections:Instituto de Investigación Biomédica de Málaga - Plataforma Bionand (IBIMA)
SAS - Hospital Universitario Virgen de la Victoria

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