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Title: Derivation of HVR1, HVR2 and HVR3 human embryonic stem cell lines from IVF embryos after preimplantation genetic diagnosis (PGD) for monogenic disorder.
Authors: Hmadcha, Abdelkrim
Aguilera, Yolanda
Lozano-Arana, Maria Dolores
Mellado, Nuria
Sánchez, Javier
Moya, Cristina
Sánchez-Palazón, Luis
Palacios, Jose
Antiñolo, Guillermo
Soria, Bernat
metadata.dc.subject.mesh: Animals
Cell Differentiation
Cells, Cultured
Cellular Reprogramming
Chromosomes, Human, Pair 15
Chromosomes, Human, Pair 9
Fertilization in Vitro
Hemophilia B
Human Embryonic Stem Cells
Mice, SCID
Microscopy, Fluorescence
Muscular Dystrophies
Preimplantation Diagnosis
Translocation, Genetic
Issue Date: 31-Mar-2016
Abstract: From 106 human blastocyts donate for research after in vitro fertilization (IVF) and preimplantation genetic diagnosis (PGD) for monogenetic disorder, 3 human embryonic stem cells (hESCs) HVR1, HVR2 and HVR3 were successfully derived. HVR1 was assumed to be genetically normal, HVR2 carrying Becker muscular dystrophy and HVR3 Hemophilia B. Despite the translocation t(9;15)(q34.3;q14) detected in HVR2, all the 3 cell lines were characterised in vitro and in vivo as normal hESCs lines and were registered in the Spanish Stem Cell Bank.
metadata.dc.identifier.doi: 10.1016/j.scr.2016.03.012
Appears in Collections:Producción 2020

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