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Title: Infective endocarditis in hypertrophic cardiomyopathy: A multicenter, prospective, cohort study.
Authors: Dominguez, Fernando
Ramos, Antonio
Bouza, Emilio
Muñoz, Patricia
Valerio, Maricela C
Fariñas, M Carmen
de Berrazueta, José Ramón
Zarauza, Jesús
Pericás Pulido, Juan Manuel
Paré, Juan Carlos
de Alarcón, Arístides
Sousa, Dolores
Rodriguez Bailón, Isabel
Montejo-Baranda, Miguel
Noureddine, Mariam
García Vázquez, Elisa
Garcia-Pavia, Pablo
metadata.dc.subject.mesh: Aged
Cardiomyopathy, Hypertrophic
Cohort Studies
Endocarditis, Bacterial
Middle Aged
Prospective Studies
Issue Date: 2016
Abstract: Infective endocarditis (IE) complicating hypertrophic cardiomyopathy (HCM) is a poorly known entity. Although current guidelines do not recommend IE antibiotic prophylaxis (IEAP) in HCM, controversy remains.This study sought to describe the clinical course of a large series of IE HCM and to compare IE in HCM patients with IE patients with and without an indication for IEAP.Data from the GAMES IE registry involving 27 Spanish hospitals were analyzed. From January 2008 to December 2013, 2000 consecutive IE patients were prospectively included in the registry. Eleven IE HCM additional cases from before 2008 were also studied. Clinical, microbiological, and echocardiographic characteristics were analyzed in IE HCM patients (n = 34) and in IE HCM reported in literature (n = 84). Patients with nondevice IE (n = 1807) were classified into 3 groups: group 1, HCM with native-valve IE (n = 26); group 2, patients with IEAP indication (n = 696); group 3, patients with no IEAP indication (n = 1085). IE episode and 1-year follow-up data were gathered.One-year mortality in IE HCM was 42% in our study and 22% in the literature. IE was more frequent, although not exclusive, in obstructive HCM (59% and 74%, respectively). Group 1 exhibited more IE predisposing factors than groups 2 and 3 (62% vs 40% vs 50%, P 
metadata.dc.identifier.doi: 10.1097/MD.0000000000004008
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