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Title: UGT2B17 minor histocompatibility mismatch and clinical outcome after HLA-identical sibling donor stem cell transplantation.
Authors: Santos, N
Rodríguez-Romanos, R
Nieto, J B
Buño, I
Vallejo, C
Jiménez-Velasco, A
Brunet, S
Buces, E
López-Jiménez, J
González, M
Ferrá, C
Sampol, A
de la Cámara, R
Martínez, C
Gallardo, D
GvHD/Immunotherapy Working Party of the Spanish Group of Hematopoietic Transplant (GETH)
metadata.dc.subject.mesh: Acute Disease
Child, Preschool
Disease-Free Survival
Graft vs Host Disease
HLA Antigens
Hematopoietic Stem Cell Transplantation
Middle Aged
Sex Factors
Survival Rate
Tissue Donors
Issue Date: 14-Sep-2015
Abstract: Minor histocompatibility Ags (mHags) have been implicated in the pathogenesis of GVHD after allogeneic hematopoietic stem cell transplantation (HSCT). Uridine diphospho-glucuronosyltransferase 2B17 (UGT2B17) gene deletion may act as a mHag and its association with acute GVHD (aGVHD) has been described. We retrospectively studied the clinical impact of a UGT2B17 mismatch in a cohort of 1127 patients receiving a HSCT from an HLA-identical sibling donor. UGT2B17 mismatch was present in 69 cases (6.1%). Incidence of severe aGVHD was higher in the UGT2B17 mismatched pairs (22.7% vs 14.6%), but this difference was not statistically significant (P: 0.098). We did not detect differences in chronic GVHD, overall survival, relapse-free survival, transplant-related mortality or relapse. Nevertheless, when we analyzed only those patients receiving grafts from a male donor (616 cases), aGVHD was significantly higher in the UGT2B17 mismatched group (25.1% vs 12.8%; P: 0.005) and this association was confirmed by the multivariate analysis (P: 0.043; hazard ratio: 2.16, 95% confidence interval: 1.03-4.57). Overall survival was worse for patients mismatched for UGT2B17 (P: 0.005). We conclude that UGT2B17 mismatch has a negative clinical impact in allogeneic HSCT from HLA-identical sibling donors only when a male donor is used. These results should be confirmed by other studies.
metadata.dc.identifier.doi: 10.1038/bmt.2015.207
Appears in Collections:Producción 2020

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