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Title: Night shift work and chronic lymphocytic leukemia in the MCC-Spain case-control study.
Authors: Costas, Laura
Benavente, Yolanda
Olmedo-Requena, Rocío
Casabonne, Delphine
Robles, Claudia
Gonzalez-Barca, Eva-Maria
de la Banda, Esmeralda
Alonso, Esther
Aymerich, Marta
Tardón, Adonina
Marcos-Gragera, Rafael
Gimeno-Vázquez, Eva
Gómez-Acebo, Inés
Papantoniou, Kyriaki
Castaño-Vinyals, Gemma
Aragonés, Nuria
Pollán, Marina
Kogevinas, Manolis
de Sanjosé, Silvia
Keywords: case-control study;chronic lymphocytic leukemia;night shift work
metadata.dc.subject.mesh: Adult
Case-Control Studies
Circadian Rhythm
Leukemia, Lymphocytic, Chronic, B-Cell
Odds Ratio
Regression Analysis
Risk Factors
Surveys and Questionnaires
Work Schedule Tolerance
Young Adult
Issue Date: 27-Jul-2016
Abstract: Chronic lymphocytic leukemia (CLL) has few known modifiable risk factors. Recently, circadian disruption has been proposed as a potential contributor to lymphoid neoplasms' etiology. Serum melatonin levels have been found to be significantly lower in CLL subjects compared with healthy controls, and also, CLL prognosis has been related to alterations in the circadian molecular signaling. We performed the first investigation of an association between night shift work and CLL in 321 incident CLL cases and 1728 population-based controls in five areas of Spain. Participants were interviewed face-to-face by trained interviewers to collect information on sociodemographic factors, familial, medical and occupational history, including work shifts and other lifestyle factors. We used logistic regression models adjusted for potential confounders to estimate odds ratios (OR) and 95% confidence intervals (CI). Seventy-nine cases (25%) and 339 controls (20%) had performed night work. Overall, working in night shifts was not associated with CLL (OR = 1.06; 95% CI = 0.78-1.45, compared with day work). However, long-term night shift (>20 years) was positively associated with CLL (OR(tertile 3 vs . day-work)  = 1.77; 95% = 1.14-2.74), although no linear trend was observed (P trend = 0.18). This association was observed among those with rotating (OR(tertile 3 vs . day-work)  = 2.29; 95% CI = 1.33-3.92; P trend = 0.07), but not permanent night shifts (OR(tertile 3 vs . day-work) = 1.16; 95% CI = 0.60-2.25; P trend = 0.86). The association between CLL and long-term rotating night shift warrants further investigation.
metadata.dc.identifier.doi: 10.1002/ijc.30272
Appears in Collections:Producción 2020

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