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Title: The role of daily physical activity and nutritional status on bone turnover in cystic fibrosis: a cross-sectional study.
Authors: Tejero, Sergio
Cejudo, Pilar
Quintana-Gallego, E
Sañudo, Borja
Oliva-Pascual-Vaca, A
metadata.dc.subject.mesh: Absorptiometry, Photon
Bone Density
Bone Remodeling
Cross-Sectional Studies
Cystic Fibrosis
Nutritional Status
Vitamin D
Vitamin K
Issue Date: 2016
Abstract: Nutritional status and daily physical activity (PA) may be an excellent tool for the maintenance of bone health in patients with cystic fibrosis (CF). To evaluate the relationship between nutritional status, daily physical activity and bone turnover in cystic fibrosis patients. A cross-sectional study of adolescent and adult patients diagnosed with clinically stable cystic fibrosis was conducted. Total body, femoral neck, and lumbar spine bone mineral density (BMD) were determined by dual energy X-ray absorptiometry and bone metabolism markers ALP, P1NP, PICP, and ß-CrossLaps. PA monitoring was assessed for 5 consecutive days using a portable device. Exercise capacity was also determined. Serum 25-hydroxyvitamin D and vitamin K were also determined in all participants. Fifty patients (median age: 24.4 years; range: 16-46) were included. BMI had positive correlation with all BMD parameters, with Spearman's coefficients ranging from 0.31 to 0.47. Total hip bone mineral density and femoral neck BMD had positive correlation with the daily time spent on moderate PA (>4.8 metabolic equivalent-minutes/day; r=0.74, p4.8 metabolic equivalent-minutes/day; r=0.74, p7.2 metabolic equivalent-minutes/day; r=0.45 p BMI and the daily time spent on moderate PA were found to be correlated with femoral neck BMD in CF patients. The association between daily PA and biochemical markers of bone formation suggests that the level of daily PA may be linked to bone health in this patient group. Further research is needed to confirm these findings.
metadata.dc.identifier.doi: 10.1590/bjpt-rbf.2014.0154
Appears in Collections:Producción 2020

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