Please use this identifier to cite or link to this item:
Title: A common variant within the HNF1B gene is associated with overall survival of multiple myeloma patients: results from the IMMEnSE consortium and meta-analysis.
Authors: Ríos-Tamayo, Rafael
Lupiañez, Carmen Belén
Campa, Daniele
Hielscher, Thomas
Weinhold, Niels
Martínez-López, Joaquin
Jerez, Andrés
Landi, Stefano
Jamroziak, Krzysztof
Dumontet, Charles
Wątek, Marzena
Lesueur, Fabienne
Reis, Rui Manuel
Marques, Herlander
Jurczyszyn, Artur
Vogel, Ulla
Buda, Gabriele
García-Sanz, Ramón
Orciuolo, Enrico
Petrini, Mario
Vangsted, Annette J
Gemignani, Federica
Försti, Asta
Goldschmidt, Hartmut
Hemminki, Kari
Canzian, Federico
Jurado, Manuel
Sainz, Juan
Keywords: diabetes;genetic variants;multiple myeloma;survival
metadata.dc.subject.mesh: Diabetes Mellitus, Type 2
Gene Frequency
Genetic Predisposition to Disease
Genome-Wide Association Study
Hepatocyte Nuclear Factor 1-beta
Multiple Myeloma
Polymorphism, Single Nucleotide
Sex Factors
Survival Analysis
Zinc Transporter 8
Issue Date: 2016
Abstract: Diabetogenic single nucleotide polymorphisms (SNPs) have recently been associated with multiple myeloma (MM) risk but their impact on overall survival (OS) of MM patients has not been analysed yet. In order to investigate the impact of 58 GWAS-identified variants for type 2 diabetes (T2D) on OS of patients with MM, we analysed genotyping data of 936 MM patients collected by the International Multiple Myeloma rESEarch (IMMENSE) consortium and an independent set of 700 MM patients recruited by the University Clinic of Heidelberg. A meta-analysis of the cox regression results of the two sets showed that rs7501939 located in the HNF1B gene negatively impacted OS (HRRec= 1.44, 95% CI = 1.18-1.76, P = 0.0001). The meta-analysis also showed a noteworthy gender-specific association of the SLC30A8rs13266634 SNP with OS. The presence of each additional copy of the minor allele at rs13266634 was associated with poor OS in men whereas no association was seen in women (HRMen-Add = 1.32, 95% CI 1.13-1.54, P = 0.0003). In conclusion, these data suggest that the HNF1Brs7501939 SNP confers poor OS in patients with MM and that a SNP in SLC30A8 affect OS in men.
metadata.dc.identifier.doi: 10.18632/oncotarget.10665
Appears in Collections:Producción 2020

Files in This Item:
File SizeFormat 
PMC5312293.pdf5,64 MBAdobe PDFView/Open

This item is protected by original copyright

This item is licensed under a Creative Commons License Creative Commons