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Title: Interaction of an S100A9 gene variant with saturated fat and carbohydrates to modulate insulin resistance in 3 populations of different ancestries.
Authors: Blanco-Rojo, Ruth
Delgado-Lista, Javier
Lee, Yu-Chi
Lai, Chao-Qiang
Perez-Martinez, Pablo
Rangel-Zuñiga, Oriol
Smith, Caren E
Hidalgo, Bertha
Alcala-Diaz, Juan F
Gomez-Delgado, Francisco
Parnell, Laurence D
Arnett, Donna K
Tucker, Katherine L
Lopez-Miranda, Jose
Ordovas, Jose M
Keywords: SFA:carbohydrate ratio; S100A9 gene;gene-diet interaction;insulin resistance;type 2 diabetes
metadata.dc.subject.mesh: Adult
Diabetes Mellitus, Type 2
Dietary Carbohydrates
Dietary Fats
Feeding Behavior
Gene-Environment Interaction
Insulin Resistance
Middle Aged
Odds Ratio
Polymorphism, Single Nucleotide
S100 Proteins
Issue Date: 20-Jul-2016
Abstract: S100 calcium-binding protein A9 (S100A9) has previously been identified as a type 2 diabetes (T2D) gene. However, this finding requires independent validation and more in-depth analyses in other populations and ancestries. We aimed to replicate the associations between an S100A9 variant and insulin resistance and T2D and to initiate an investigation of potential interactions with the habitual diet in several independent populations. We investigated the association of the S100A9 variant rs3014866 with insulin resistance and T2D risk and its interactions with diet in 3 diverse populations as follows: the CORDIOPREV (Coronary Diet Intervention with Olive Oil and Cardiovascular Prevention; n = 711), which consisted of Spanish white adults; the GOLDN (Genetics of Lipids Lowering Drugs and Diet Network; n = 818), which involved North American non-Hispanic white adults; and Hispanic adults who participated in the BPRHS (Boston Puerto Rican Health Study; n = 1155). Meta-analysis indicated that T carriers presented a lower risk of T2D than CC carriers (pooled OR: 0.714; 95% CI: 0.584, 0.845; P = 0.002). In all 3 populations (CORDIOPREV, GOLDN, and BPRHS), we showed a significant interaction between the rs3014866 single nucleotide polymorphism and dietary SFA:carbohydrate ratio intake for the homeostasis model assessment of insulin resistance (HOMA-IR) (P = 0.028, P = 0.017, and P = 0.026, respectively). CC carriers had a significantly higher HOMA-IR only when SFA:carbohydrate intake was high (P = 0.045 for the CORDIOPREV, P = 0.033 for the GOLDN, and P = 0.046 for the BPRHS) but not when SFA:carbohydrate ratio intake was low. The minor allele (T) of the S100A9 variant rs3014866 is associated with lower T2D risk in 3 populations of different ancestries. Note that individuals with the high-risk CC genotype may be more likely to benefit from a low SFA:carbohydrate ratio intake to improve insulin resistance as evaluated with the use of the HOMA-IR. These trials were registered at as NCT00924937 (CORDIOPREV), NCT00083369 (GOLDN), and NCT01231958 (BPRHS).
metadata.dc.identifier.doi: 10.3945/ajcn.116.130898
Appears in Collections:Producción 2020

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