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Title: Effect of Monotherapy with Darunavir/Ritonavir on Viral Load in Seminal Fluid, and Quality Parameters of Semen in HIV-1-Positive Patients.
Authors: Lopez-Ruz, Miguel A
Navas, Purificación
López-Zúñiga, Miguel A
Gonzalvo, María Carmen
Sampedro, Antonio
Pasquau, Juan
Hidalgo-Tenorio, Carmen
Javier, Rosario
Castilla, José A
metadata.dc.subject.mesh: Adult
Antiretroviral Therapy, Highly Active
Drug Therapy, Combination
HIV Infections
Viral Load
Issue Date: 21-Jul-2016
Abstract: Patients with human immunodeficiency virus type 1 (HIV-1) who receive antiretroviral therapy (ART) often achieve increased survival and improved quality of life. In this respect, monotherapy with darunavir/ritonavir (mDRV/r) can be a useful treatment strategy. This prospective study analyses the effect of mDRV/r on sperm quality and viral load in a group of 28 patients who had previously been given conventional ART and who had recorded a viral load 20 copies/ml), and that at V1, after mDRV/r treatment, this figure had fallen to 3%. The quality of seminal fluid was close to normal in 57% of patients at V0 and in 62% at V1. We conclude that, similar to ART, mDRV/r maintains HIV-1 viral load in most patients, and that there is no worsening in seminal fluid quality.
metadata.dc.identifier.doi: 10.1371/journal.pone.0159305
Appears in Collections:Producción 2020

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