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|Title:||Bronchopulmonary infection-colonization patterns in Spanish cystic fibrosis patients: Results from a national multicenter study.|
|Authors:||de Dios Caballero, Juan|
Del Campo, Rosa
de Gracia, Javier
de la Pedrosa, Elia Gómez G
GEIFQ (Grupo Español para el Estudio de la Colonización/Infección Broncopulmonar en Fibrosis Quística)
|Keywords:||Cystic fibrosis;P. aeruginosa;Pulmonary infection–colonization;Respiratory pathogens|
Methicillin-Resistant Staphylococcus aureus
Respiratory Function Tests
|Abstract:||Clinical and demographical knowledge on Spanish cystic fibrosis (CF) patients is incomplete as no national registry exists. CF-microbiology has not been studied at national level. The results of the first Spanish multicenter study on CF microbiology are presented. 24 CF-Units for adult (n=12) and pediatric (n=12) patients from 17 hospitals provided sputa and clinical data from 15 consecutive patients. Cultures and susceptibility testing were performed. Colonization impact on pulmonary function was assessed. 341 patients [mean (SD) age 21 (11) years, 180≥18years, mean (SD) FEV1=68 (25)%] were included. Pseudomonas aeruginosa was reported as chronic, intermittent or absent in 46%, 22% and 32% of patients, respectively. The annual prevalence was 62%. Positive P. aeruginosa and methicillin-resistant Staphylococcus aureus cultures were significantly associated with lower FEV1 (p The representative subset of the Spanish CF-population which has been clinically, demographically and microbiologically characterized will serve as a reference for future CF studies in Spain.|
|Appears in Collections:||Producción 2020|
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