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Title: Bronchopulmonary infection-colonization patterns in Spanish cystic fibrosis patients: Results from a national multicenter study.
Authors: de Dios Caballero, Juan
Del Campo, Rosa
Royuela, Ana
Solé, Amparo
Máiz, Luis
Olveira, Casilda
Quintana-Gallego, Esther
de Gracia, Javier
Cobo, Marta
de la Pedrosa, Elia Gómez G
Oliver, Antonio
Cantón, Rafael
GEIFQ (Grupo Español para el Estudio de la Colonización/Infección Broncopulmonar en Fibrosis Quística)
Keywords: Cystic fibrosis;P. aeruginosa;Pulmonary infection–colonization;Respiratory pathogens
metadata.dc.subject.mesh: Adolescent
Anti-Bacterial Agents
Cystic Fibrosis
Methicillin-Resistant Staphylococcus aureus
Prospective Studies
Pseudomonas Infections
Pseudomonas aeruginosa
Respiratory Function Tests
Staphylococcal Infections
Issue Date: 28-Sep-2015
Abstract: Clinical and demographical knowledge on Spanish cystic fibrosis (CF) patients is incomplete as no national registry exists. CF-microbiology has not been studied at national level. The results of the first Spanish multicenter study on CF microbiology are presented. 24 CF-Units for adult (n=12) and pediatric (n=12) patients from 17 hospitals provided sputa and clinical data from 15 consecutive patients. Cultures and susceptibility testing were performed. Colonization impact on pulmonary function was assessed. 341 patients [mean (SD) age 21 (11) years, 180≥18years, mean (SD) FEV1=68 (25)%] were included. Pseudomonas aeruginosa was reported as chronic, intermittent or absent in 46%, 22% and 32% of patients, respectively. The annual prevalence was 62%. Positive P. aeruginosa and methicillin-resistant Staphylococcus aureus cultures were significantly associated with lower FEV1 (p The representative subset of the Spanish CF-population which has been clinically, demographically and microbiologically characterized will serve as a reference for future CF studies in Spain.
metadata.dc.identifier.doi: 10.1016/j.jcf.2015.09.004
Appears in Collections:Producción 2020

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