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Title: Geometrical Measures Obtained from Pretreatment Postcontrast T1 Weighted MRIs Predict Survival Benefits from Bevacizumab in Glioblastoma Patients.
Authors: Molina, David
Pérez-Beteta, Julián
Martínez-González, Alicia
Sepúlveda, Juan M
Peralta, Sergi
Gil-Gil, Miguel J
Reynes, Gaspar
Herrero, Ana
De Las Peñas, Ramón
Luque, Raquel
Capellades, Jaume
Balaña, Carmen
Pérez-García, Víctor M
metadata.dc.subject.mesh: Adult
Angiogenesis Inhibitors
Antineoplastic Agents
Antineoplastic Combined Chemotherapy Protocols
Brain Neoplasms
Image Processing, Computer-Assisted
Kaplan-Meier Estimate
Magnetic Resonance Imaging
Middle Aged
Neoadjuvant Therapy
Proportional Hazards Models
Treatment Outcome
Tumor Burden
Issue Date: 24-Aug-2016
Abstract: Antiangiogenic therapies for glioblastoma (GBM) such as bevacizumab (BVZ), have been unable to extend survival in large patient cohorts. However, a subset of patients having angiogenesis-dependent tumors might benefit from these therapies. Currently, there are no biomarkers allowing to discriminate responders from non-responders before the start of the therapy. 40 patients from the randomized GENOM009 study complied the inclusion criteria (quality of images, clinical data available). Of those, 23 patients received first line temozolomide (TMZ) for eight weeks and then concomitant radiotherapy and TMZ. 17 patients received BVZ+TMZ for seven weeks and then added radiotherapy to the treatment. Clinical variables were collected, tumors segmented and several geometrical measures computed including: Contrast enhancing (CE), necrotic, and total volumes; equivalent spherical CE width; several geometric measures of the CE 'rim' geometry and a set of image texture measures. The significance of the results was studied using Kaplan-Meier and Cox proportional hazards analysis. Correlations were assessed using Spearman correlation coefficients. Kaplan-Meier and Cox proportional hazards analysis showed that total, CE and inner volume (p = 0.019, HR = 4.258) and geometric heterogeneity of the CE areas (p = 0.011, HR = 3.931) were significant parameters identifying response to BVZ. The group of patients with either regular CE areas (small geometric heterogeneity, median difference survival 15.88 months, p = 0.011) or those with small necrotic volume (median survival difference 14.50 months, p = 0.047) benefited substantially from BVZ. Imaging biomarkers related to the irregularity of contrast enhancing areas and the necrotic volume were able to discriminate GBM patients with a substantial survival benefit from BVZ. A prospective study is needed to validate our results.
metadata.dc.identifier.doi: 10.1371/journal.pone.0161484
Appears in Collections:Producción 2020

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