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Title: Clinical, virological and phylogenetic characterization of a multiresistant HIV-1 strain outbreak in naive patients in southern Spain.
Authors: Viciana, I
González-Domenech, C M
Palacios, R
Delgado, M
Del Arco, A
Tellez, F
Jarilla, F
Fernández, S
Clavijo, E
Santos, J
metadata.dc.subject.mesh: Adult
Anti-Retroviral Agents
Cluster Analysis
Disease Outbreaks
Disease Transmission, Infectious
Drug Resistance, Multiple, Viral
HIV Infections
HIV Reverse Transcriptase
Middle Aged
Molecular Epidemiology
Mutation, Missense
Sequence Analysis, DNA
Sequence Homology
Issue Date: 19-Oct-2015
Abstract: We describe the characteristics of an HIV-1 strain with six viral reverse transcriptase mutations (D67N, T69N/D, V118I, V179D, T215S and K219Q), which we have called the Malaga strain. This strain was detected in treatment-naive patients from southern Spain. The study was undertaken at the Virgen de la Victoria Hospital, Malaga, a reference centre for the study of HIV-1 genotype resistance in Andalusia (the 'Costa del Sol'), Spain. Genotypic resistance testing was done in an automated sequencer. Phylogenetic analysis was performed using a 630 bp region of the reverse transcriptase with the mutations mentioned. Between 2007 and 2014, we detected the Malaga strain in 30 treatment-naive patients. All were MSM, seen at five hospitals on the Costa del Sol. In all cases, the HIV-1 was subtype B with viral tropism R5. Phylogenetic analysis based on the reverse transcriptase sequence showed consistent grouping (with a bootstrap value of the common node of 100%) of the isolates that shared the mutation pattern mentioned. This strain has not been detected elsewhere or in previously treated patients. All of the patients treated with first-line combination ART responded. We report a cluster of an HIV-1 strain with multiple resistance mutations that was transmitted over a period of >8 years, affecting 30 naive patients from the same geographical area. The strain was susceptible to first-line combination ART.
metadata.dc.identifier.doi: 10.1093/jac/dkv332
Appears in Collections:Producción 2020

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