Please use this identifier to cite or link to this item:
Title: Metabolites of Glutamate Metabolism Are Associated With Incident Cardiovascular Events in the PREDIMED PREvención con DIeta MEDiterránea (PREDIMED) Trial.
Authors: Zheng, Yan
Hu, Frank B
Ruiz-Canela, Miguel
Clish, Clary B
Dennis, Courtney
Salas-Salvado, Jordi
Hruby, Adela
Liang, Liming
Toledo, Estefania
Corella, Dolores
Ros, Emilio
Fitó, Montserrat
Gómez-Gracia, Enrique
Arós, Fernando
Fiol, Miquel
Lapetra, José
Serra-Majem, Lluis
Estruch, Ramón
Martínez-González, Miguel A
Keywords: cardiovascular disease;diet;dietary clinical trial;epidemiology;glutamate;glutamine;incidence;stroke
metadata.dc.subject.mesh: Aged
Aged, 80 and over
Cardiovascular Diseases
Cholesterol, HDL
Cholesterol, LDL
Diabetes Mellitus, Type 2
Diet, Mediterranean
Glutamic Acid
Middle Aged
Myocardial Infarction
Proportional Hazards Models
Randomized Controlled Trials as Topic
Risk Factors
Tobacco Smoking
Issue Date: 15-Sep-2016
Abstract: Glutamate metabolism may play a role in the pathophysiology of cardiometabolic disorders. However, there is limited evidence of an association between glutamate-related metabolites and, moreover, changes in these metabolites, and risk of cardiovascular disease (CVD). Plasma levels of glutamate and glutamine were measured at baseline and 1-year follow-up in a case-cohort study including 980 participants (mean age 68 years; 46% male) from the PREvención con DIeta MEDiterránea (PREDIMED) randomized trial, which assessed a Mediterranean diet intervention in the primary prevention of CVD. During median 4.8 years of follow-up, there were 229 incident CVD events (nonfatal stroke, nonfatal myocardial infarction, or CVD death). In fully adjusted models, per 1-SD, baseline glutamate was associated with 43% (95% CI: 16% to 76%) and 81% (39% to 137%) increased risk of composite CVD and stroke alone, respectively, and baseline glutamine-to-glutamate ratio with 25% (6% to 40%) and 44% (25% to 58%) decreased risk of composite CVD and stroke alone, respectively. Associations appeared linear for stroke (both Plinear trend≤0.005). Among participants with high baseline glutamate, the interventions lowered CVD risk by 37% compared to the control diet; the intervention effects were not significant when baseline glutamate was low (Pinteraction=0.02). No significant effect of the intervention on year-1 changes in metabolites was observed, and no effect of changes themselves on CVD risk was apparent. Baseline glutamate was associated with increased CVD risk, particularly stroke, and glutamine-to-glutamate ratio was associated with decreased risk. Participants with high glutamate levels may obtain greater benefits from the Mediterranean diet than those with low levels. URL: Unique identifier: ISRCTN 35739639.
metadata.dc.identifier.doi: 10.1161/JAHA.116.003755
Appears in Collections:Producción 2020

Files in This Item:
File SizeFormat 
PMC5079035.pdf549,73 kBAdobe PDFView/Open

This item is protected by original copyright

This item is licensed under a Creative Commons License Creative Commons