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Title: Meta-Analysis of Individual Patient Data of Sodium Bicarbonate and Sodium Chloride for All-Cause Mortality After Coronary Angiography.
Authors: Brown, Jeremiah R
Pearlman, Daniel M
Marshall, Emily J
Alam, Shama S
MacKenzie, Todd A
Recio-Mayoral, Alejandro
Gomes, Vitor O
Kim, Bokyung
Jensen, Lisette O
Mueller, Christian
Maioli, Mauro
Solomon, Richard J
metadata.dc.subject.mesh: Cause of Death
Contrast Media
Coronary Angiography
Coronary Artery Disease
Global Health
Glomerular Filtration Rate
Infusions, Intravenous
Renal Insufficiency, Chronic
Sodium Bicarbonate
Sodium Chloride
Survival Rate
Issue Date: 24-Aug-2016
Abstract: We sought to examine the relation between sodium bicarbonate prophylaxis for contrast-associated nephropathy (CAN) and mortality. We conducted an individual patient data meta-analysis from multiple randomized controlled trials. We obtained individual patient data sets for 7 of 10 eligible trials (2,292 of 2,764 participants). For the remaining 3 trials, time-to-event data were imputed based on follow-up periods described in their original reports. We included all trials that compared periprocedural intravenous sodium bicarbonate to periprocedural intravenous sodium chloride in patients undergoing coronary angiography or other intra-arterial interventions. Included trials were determined by consensus according to predefined eligibility criteria. The primary outcome was all-cause mortality hazard, defined as time from randomization to death. In 10 trials with a total of 2,764 participants, sodium bicarbonate was associated with lower mortality hazard than sodium chloride at 1 year (hazard ratio 0.61, 95% confidence interval [CI] 0.41 to 0.89, p = 0.011). Although periprocedural sodium bicarbonate was associated with a reduction in the incidence of CAN (relative risk 0.75, 95% CI 0.62 to 0.91, p = 0.003), there exists a statistically significant interaction between the effect on mortality and the occurrence of CAN (hazard ratio 5.65, 95% CI 3.58 to 8.92, p
metadata.dc.identifier.doi: 10.1016/j.amjcard.2016.08.008
Appears in Collections:Producción 2020

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