Please use this identifier to cite or link to this item:
Title: Short-term safety, tolerability and efficacy of a very low-calorie-ketogenic diet interventional weight loss program versus hypocaloric diet in patients with type 2 diabetes mellitus.
Authors: Goday, A
Bellido, D
Sajoux, I
Crujeiras, A B
Burguera, B
García-Luna, P P
Oleaga, A
Moreno, B
Casanueva, F F
metadata.dc.subject.mesh: Adult
Behavior Therapy
Blood Glucose
Caloric Restriction
Diabetes Mellitus, Type 2
Diet, Ketogenic
Diet, Reducing
Glycated Hemoglobin
Life Style
Middle Aged
Prospective Studies
Treatment Outcome
Waist Circumference
Weight Loss
Weight Reduction Programs
Issue Date: 19-Sep-2016
Abstract: Brackground:The safety and tolerability of very low-calorie-ketogenic (VLCK) diets are a current concern in the treatment of obese type 2 diabetes mellitus (T2DM) patients. Evaluating the short-term safety and tolerability of a VLCK diet ( Eighty-nine men and women, aged between 30 and 65 years, with T2DM and body mass index between 30 and 35 kg m(-)(2) participated in this prospective, open-label, multi-centric randomized clinical trial with a duration of 4 months. Forty-five subjects were randomly assigned to the interventional weight loss (VLCK diet), and 44 to the standard low-calorie diet. No significant differences in the laboratory safety parameters were found between the two study groups. Changes in the urine albumin-to-creatinine ratio in VLCK diet were not significant and were comparable to control group. Creatinine and blood urea nitrogen did not change significantly relative to baseline nor between groups. Weight loss and reduction in waist circumference in the VLCK diet group were significantly larger than in control subjects (both P The interventional weight loss program based on a VLCK diet is most effective in reducing body weight and improvement of glycemic control than a standard hypocaloric diet with safety and good tolerance for T2DM patients.
metadata.dc.identifier.doi: 10.1038/nutd.2016.36
Appears in Collections:Producción 2020

Files in This Item:
File SizeFormat 
PMC5048014.pdf334,8 kBAdobe PDFView/Open

This item is protected by original copyright

This item is licensed under a Creative Commons License Creative Commons