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Title: Effects of hydroxytyrosol on cardiovascular biomarkers in experimental diabetes mellitus.
Authors: López-Villodres, Juan Antonio
Abdel-Karim, Miriam
De La Cruz, José Pedro
Rodríguez-Pérez, María Dolores
Reyes, José Julio
Guzmán-Moscoso, Rocío
Rodriguez-Gutierrez, Guillermo
Fernández-Bolaños, Juan
González-Correa, José Antonio
Keywords: Diabetes;Hydroxytyrosol;Inflammatory mediators;Oxidative stress;Platelets;Vasculopathy
metadata.dc.subject.mesh: Animals
Anti-Inflammatory Agents, Non-Steroidal
Aorta, Abdominal
Cardiovascular Diseases
Diabetes Mellitus, Experimental
Diabetic Angiopathies
Diabetic Cardiomyopathies
Dietary Supplements
Endothelium, Vascular
Inflammation Mediators
Lipid Peroxidation
Lipoproteins, LDL
Muscle, Smooth, Vascular
Oxidative Stress
Phenylethyl Alcohol
Platelet Aggregation
Rats, Wistar
Reactive Nitrogen Species
Issue Date: 26-Aug-2016
Abstract: The aim of this study was to assess the influence of hydroxytyrosol (HT) on cardiovascular biomarkers and morphometric parameters of the arterial wall in streptozotocin-diabetic rats. Seven groups of rats (N=10 per group) were studied for 2 months: nondiabetic rats (NDR), diabetic rats treated with saline (DR) and DR treated with HT (0.5, 1, 2.5, 5 and 10 mg kg-1 day-1 p.o.). DR had higher platelet aggregation values, higher thromboxane B2, plasma lipid peroxidation, 3-nitrotyrosine, oxidized LDL (oxLDL), myeloperoxidase, vascular cell adhesion molecule 1 (VCAM-1) and interleukin-1β (IL-1β) concentrations, and lower aortic 6-keto-prostaglandin F1α and nitric oxide production than NDR. Aortic wall area and smooth muscle cell count were also higher in DR than in NDR. HT significantly reduced both oxidative and nitrosative stress, oxLDL concentration, VCAM-1 and inflammatory mediators, platelet aggregation and thromboxane B2 production. Morphometric values in the aortic wall were reduced to values near those in NDR. In conclusion, HT influenced the major biochemical processes leading to diabetic vasculopathy, and reduced cell proliferation in the vascular wall in this experimental model.
metadata.dc.identifier.doi: 10.1016/j.jnutbio.2016.07.015
Appears in Collections:Producción 2020

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