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Title: Growth rate controls mRNA turnover in steady and non-steady states.
Authors: García-Martínez, José
Troulé, Kevin
Chávez, Sebastián
Pérez-Ortín, José E
Keywords: Gene expression;Saccharomyces cerevisiae;growth rate;mRNA stability;transcription;yeast
metadata.dc.subject.mesh: Gene Expression Regulation, Fungal
RNA Stability
RNA, Fungal
RNA, Messenger
Saccharomyces cerevisiae
Issue Date: 20-Sep-2016
Abstract: Gene expression has been investigated in relation with growth rate in the yeast Saccharomyces cerevisiae, following different experimental strategies. The expression of some specific gene functional categories increases or decreases with growth rate. Our recently published results have unveiled that these changes in mRNA concentration with growth depend on the relative alteration of mRNA synthesis and decay, and that, in addition to this gene-specific transcriptomic signature of growth, global mRNA turnover increases with growth rate. We discuss here these results in relation with other previous and concurrent publications, and we add new evidence which indicates that growth rate controls mRNA turnover even under non-steady-state conditions.
metadata.dc.identifier.doi: 10.1080/15476286.2016.1236171
Appears in Collections:Producción 2020

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