RISalud
Institutional Health Repository of Andalucía
Please use this identifier to cite or link to this item:
http://hdl.handle.net/10668/10521| Title: | Biomarkers of Morbid Obesity and Prediabetes by Metabolomic Profiling of Human Discordant Phenotypes. |
| Authors: | Tulipani, Sara Palau-Rodriguez, Magali Miñarro Alonso, Antonio Cardona, Fernando Marco-Ramell, Anna Zonja, Bozo Lopez de Alda, Miren Muñoz-Garach, Araceli Sanchez-Pla, Alejandro Tinahones, Francisco J Andres-Lacueva, Cristina |
| Keywords: | mass spectrometry;metabolic markers;obesity;observational study;prediabetes |
| metadata.dc.subject.mesh: | Adult Biomarkers Diabetes Mellitus, Type 2 Female Humans Male Metabolomics Middle Aged Obesity, Morbid Phenotype Prediabetic State |
| Issue Date: | 5-Oct-2016 |
| Abstract: | Metabolomic studies aimed to dissect the connection between the development of type 2 diabetes and obesity are still scarce. In the present study, fasting serum from sixty-four adult individuals classified into four sex-matched groups by their BMI [non-obese versus morbid obese] and the increased risk of developing diabetes [prediabetic insulin resistant state versus non-prediabetic non-insulin resistant] was analyzed by LC- and FIA-ESI-MS/MS-driven metabolomic approaches. Altered levels of [lyso]glycerophospholipids was the most specific metabolic trait associated to morbid obesity, particularly lysophosphatidylcholines acylated with margaric, oleic and linoleic acids [lysoPC C17:0: R=-0.56, p=0.0003; lysoPC C18:1: R=-0.61, p=0.0001; lysoPC C18:2 R=-0.64, p |
| URI: | http://hdl.handle.net/10668/10521 |
| metadata.dc.identifier.doi: | 10.1016/j.cca.2016.10.005 |
| Appears in Collections: | Producción 2020 |
Files in This Item:
There are no files associated with this item.
This item is protected by original copyright |
This item is licensed under a Creative Commons License
