Please use this identifier to cite or link to this item:
Title: Short, full-dose adjuvant chemotherapy (CT) in high-risk adult soft tissue sarcomas (STS): long-term follow-up of a randomized clinical trial from the Italian Sarcoma Group and the Spanish Sarcoma Group.
Authors: Gronchi, A
Stacchiotti, S
Verderio, P
Ferrari, S
Martin Broto, J
Lopez-Pousa, A
Llombart-Bosch, A
Dei Tos, A P
Collini, P
Jurado, J Cruz
De Paoli, A
Donati, D M
Poveda, A
Quagliuolo, V
Comandone, A
Grignani, G
Morosi, C
Messina, A
De Sanctis, R
Bottelli, S
Palassini, E
Casali, P G
Picci, Piero
Keywords: adjuvant chemotherapy;quality of surgery;response;sarcoma;soft tissue sarcoma;survival
metadata.dc.subject.mesh: Adult
Chemotherapy, Adjuvant
Disease-Free Survival
Follow-Up Studies
Middle Aged
Risk Factors
Treatment Outcome
Issue Date: 11-Oct-2016
Abstract: To report on long-term results of a phase 3 trial comparing three versus five cycles of adjuvant chemotherapy (CT) with full-dose epirubicin+ifosfamide in high-risk soft tissue sarcomas (STS). Patients (pts) were randomized to receive three preoperative cycles of epirubicin 120 mg/m2 and ifosfamide 9 g/m2 (Arm A) or to receive the same three preoperative cycles plus two postoperative cycles (Arm B). Radiotherapy could be either delivered in the preoperative or in the postoperative setting. Non-inferiority of the primary end point, OS, was assessed by the confidence interval of the hazard ratio (HR; Arm A/Arm B) derived from Cox model. Between January 2002 and April 2007, 164 pts were assigned to arm A and 164 to arm B. At a median follow-up (FU) of 117 months (IQ range 103-135 months), 123 deaths were recorded: 58 in Arm A and 65 in Arm B. Ten-year OS was 61% for the entire group of patients: 64% in Arm A and 59% in Arm B. The intention-to-treat analysis confirmed that three cycles were not inferior to five cycles (one-sided 95% upper confidence limit was 1.24). A per protocol analysis was consistent with these results. Pts with leiomyosarcoma and undifferentiated pleomorphic sarcoma (UPS) had the lowest, and the highest response rates, respectively. Consistently, Leiomyosarcoma and UPS had the worse and the best prognosis, respectively. At a longer FU, the non-inferiority of three cycles of a full-dose conventional CT in comparison to five is confirmed. Response to therapy is also confirmed to be associated with better survival. This regimen is currently tested within an ongoing international trial against three cycles of a neoadjuvant histology-tailored CT ( Identifier: NCT01710176).
metadata.dc.identifier.doi: 10.1093/annonc/mdw430
Appears in Collections:Producción 2020

Files in This Item:
There are no files associated with this item.

This item is protected by original copyright

Except where otherwise noted, Items on the Andalusian Health Repository site are licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives License.