Please use this identifier to cite or link to this item:
Title: Two Healthy Diets Modulate Gut Microbial Community Improving Insulin Sensitivity in a Human Obese Population.
Authors: Haro, Carmen
Montes-Borrego, Miguel
Rangel-Zúñiga, Oriol A
Alcalá-Díaz, Juan F
Gómez-Delgado, Francisco
Pérez-Martínez, Pablo
Delgado-Lista, Javier
Quintana-Navarro, Gracia M
Tinahones, Francisco J
Landa, Blanca B
López-Miranda, José
Camargo, Antonio
Pérez-Jiménez, Francisco
metadata.dc.subject.mesh: DNA, Bacterial
Diet, Fat-Restricted
Diet, Mediterranean
Dietary Carbohydrates
Gastrointestinal Tract
Insulin Resistance
Middle Aged
Olive Oil
Prospective Studies
Issue Date: 27-Oct-2015
Abstract: Gut microbiota, which acts collectively as a fully integrated organ in the host metabolism, can be shaped by long-term dietary interventions after a specific diet. The aim was to study the changes in microbiota after 1 year's consumption of a Mediterranean diet (Med diet) or a low-fat, high-complex carbohydrate diet (LFHCC diet) in an obese population. Participants were randomized to receive the Med diet (35% fat, 22% monounsaturated) and the LFHCC diet (28% fat, 12% monounsaturated). The study was conducted in 20 obese patients (men) within the Coronary Diet Intervention With Olive Oil and Cardiovascular Prevention (CORDIOPREV) study, an ongoing prospective, randomized, opened, controlled trial in patients with coronary heart disease. We evaluated the bacterial composition and its relationship with the whole fecal and plasma metabolome. The LFHCC diet increased the Prevotella and decreased the Roseburia genera, whereas the Med diet decreased the Prevotella and increased the Roseburia and Oscillospira genera (P = .028, .002, and .016, respectively). The abundance of Parabacteroides distasonis (P = .025) and Faecalibacterium prausnitzii (P = .020) increased after long-term consumption of the Med diet and the LFHCC diet, respectively. The changes in the abundance of 7 of 572 metabolites found in feces, including mainly amino acid, peptide, and sphingolipid metabolism, could be linked to the changes in the gut microbiota. Our results suggest that long-term consumption of the Med and LFHCC diets exerts a protective effect on the development of type 2 diabetes by different specific changes in the gut microbiota, increasing the abundance of the Roseburia genus and F. prausnitzii, respectively.
metadata.dc.identifier.doi: 10.1210/jc.2015-3351
Appears in Collections:Producción 2020

Files in This Item:
There are no files associated with this item.

This item is protected by original copyright

Except where otherwise noted, Items on the Andalusian Health Repository site are licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives License.