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Title: Goat whey ameliorates intestinal inflammation on acetic acid-induced colitis in rats.
Authors: Araújo, Daline Fernandes de Souza
Guerra, Gerlane Coelho Bernardo
Júnior, Raimundo Fernandes de Araújo
Antunes de Araújo, Aurigena
Antonino de Assis, Paloma Oliveira
Nunes de Medeiros, Ariosvaldo
Formiga de Sousa, Yasmim Regis
Pintado, Maria Manuela Estevez
Gálvez, Julio
Queiroga, Rita de Cássia Ramos do Egypto
Keywords: cytokines;goat whey;immunohistochemical;intestinal inflammation;oxidative stress
metadata.dc.subject.mesh: Acetic Acid
Rats, Wistar
Trinitrobenzenesulfonic Acid
Issue Date: 19-Oct-2016
Abstract: Complementary or alternative medicine is of great interest for the treatment of inflammatory bowel disease, with the aim of ameliorating the side effects of the drugs commonly used or improving their efficacy. In this study, we evaluated the ability of goat whey to prevent intestinal inflammation in the experimental model of acetic acid-induced rats and compared it to sulfasalazine. Pretreatment with goat whey (1, 2, and 4g/kg) and sulfasalazine (250mg/kg) on colitic rats improved colonic inflammatory markers, including myeloperoxidase activity, leukotriene B4 levels, as well as the production of proinflammatory cytokines IL-1β and tumor necrosis factor-α. Furthermore, the administration of goat whey significantly reduced the colonic oxidative stress by reducing malondialdehyde levels and increased total glutathione content, a potent antioxidant peptide. The histological evaluation of the colonic specimens from colitic rats confirmed these beneficial effects, as goat whey preserved the colonic tissue, especially in those rats treated with the highest dose of goat whey or with sulfasalazine. The immunohistochemistry analysis of the colonic tissue evaluation also revealed a reduction in the expression of cyclooxygenase-2, inducible nitric oxide synthase, and matrix metalloproteinase-9, together with an increased expression of suppressor of cytokine signaling-1. These results suggest that goat whey exerted a preventive effect against the intestinal damage induced by acetic acid, showing a similar efficacy to that shown by sulfasalazine, therefore making it a potential treatment for human inflammatory bowel disease.
metadata.dc.identifier.doi: 10.3168/jds.2016-10930
Appears in Collections:Producción 2020

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