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Title: Impact of CTLA4 genotype and other immune response gene polymorphisms on outcomes after single umbilical cord blood transplantation.
Authors: Cunha, Renato
Zago, Marco A
Querol, Sergio
Volt, Fernanda
Ruggeri, Annalisa
Sanz, Guillermo
Pouthier, Fabienne
Kogler, Gesine
Vicario, José L
Bergamaschi, Paola
Saccardi, Riccardo
Lamas, Carmen H
Díaz-de-Heredia, Cristina
Michel, Gerard
Bittencourt, Henrique
Tavella, Marli
Panepucci, Rodrigo A
Fernandes, Francisco
Pavan, Julia
Gluckman, Eliane
Rocha, Vanderson
Eurocord, Cord Blood Committee Cellular Therapy–Immunobiology Working Party of the European Society for Blood and Marrow Transplantation, Netcord and Faculdade de Medicina de Ribeirão Preto–Faculdade de Medicina de São Paulo, Universidade de São Paulo
metadata.dc.subject.mesh: Adaptor Proteins, Signal Transducing
Apoptosis Regulatory Proteins
CTLA-4 Antigen
Child, Preschool
Cord Blood Stem Cell Transplantation
Disease-Free Survival
Fetal Blood
Gene Expression
HLA Antigens
Hematologic Neoplasms
Histocompatibility Testing
Middle Aged
Myeloablative Agonists
NLR Proteins
Polymorphism, Genetic
Proportional Hazards Models
Protein Isoforms
Retrospective Studies
Transplantation Conditioning
Unrelated Donors
Issue Date: 3-Nov-2016
Abstract: We evaluated the impact of recipient and cord blood unit (CBU) genetic polymorphisms related to immune response on outcomes after unrelated cord blood transplantations (CBTs). Pretransplant DNA samples from 696 CBUs with malignant diseases were genotyped for NLRP1, NLRP2, NLRP3, TIRAP/Mal, IL10, REL, TNFRSF1B, and CTLA4. HLA compatibility was 6 of 6 in 10%, 5 of 6 in 39%, and ≥4 of 6 in 51% of transplants. Myeloablative conditioning was used in 80%, and in vivo T-cell depletion in 81%, of cases. The median number of total nucleated cells infused was 3.4 × 107/kg. In multivariable analysis, patients receiving CBUs with GG-CTLA4 genotype had poorer neutrophil recovery (hazard ratio [HR], 1.33; P = .02), increased nonrelapse mortality (NRM) (HR, 1.50; P
metadata.dc.identifier.doi: 10.1182/blood-2016-06-722249
Appears in Collections:Producción 2020

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