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http://hdl.handle.net/10668/10578| Title: | Impact of CTLA4 genotype and other immune response gene polymorphisms on outcomes after single umbilical cord blood transplantation. |
| Authors: | Cunha, Renato Zago, Marco A Querol, Sergio Volt, Fernanda Ruggeri, Annalisa Sanz, Guillermo Pouthier, Fabienne Kogler, Gesine Vicario, José L Bergamaschi, Paola Saccardi, Riccardo Lamas, Carmen H Díaz-de-Heredia, Cristina Michel, Gerard Bittencourt, Henrique Tavella, Marli Panepucci, Rodrigo A Fernandes, Francisco Pavan, Julia Gluckman, Eliane Rocha, Vanderson Eurocord, Cord Blood Committee Cellular Therapy–Immunobiology Working Party of the European Society for Blood and Marrow Transplantation, Netcord and Faculdade de Medicina de Ribeirão Preto–Faculdade de Medicina de São Paulo, Universidade de São Paulo |
| metadata.dc.subject.mesh: | Adaptor Proteins, Signal Transducing Adolescent Adult Alleles Apoptosis Regulatory Proteins CTLA-4 Antigen Child Child, Preschool Cord Blood Stem Cell Transplantation Disease-Free Survival Female Fetal Blood Gene Expression Genotype HLA Antigens Hematologic Neoplasms Histocompatibility Testing Humans Infant Male Middle Aged Myeloablative Agonists NLR Proteins Polymorphism, Genetic Proportional Hazards Models Protein Isoforms Retrospective Studies Transplantation Conditioning Unrelated Donors |
| Issue Date: | 3-Nov-2016 |
| Abstract: | We evaluated the impact of recipient and cord blood unit (CBU) genetic polymorphisms related to immune response on outcomes after unrelated cord blood transplantations (CBTs). Pretransplant DNA samples from 696 CBUs with malignant diseases were genotyped for NLRP1, NLRP2, NLRP3, TIRAP/Mal, IL10, REL, TNFRSF1B, and CTLA4. HLA compatibility was 6 of 6 in 10%, 5 of 6 in 39%, and ≥4 of 6 in 51% of transplants. Myeloablative conditioning was used in 80%, and in vivo T-cell depletion in 81%, of cases. The median number of total nucleated cells infused was 3.4 × 107/kg. In multivariable analysis, patients receiving CBUs with GG-CTLA4 genotype had poorer neutrophil recovery (hazard ratio [HR], 1.33; P = .02), increased nonrelapse mortality (NRM) (HR, 1.50; P |
| URI: | http://hdl.handle.net/10668/10578 |
| metadata.dc.identifier.doi: | 10.1182/blood-2016-06-722249 |
| Appears in Collections: | Producción 2020 |
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