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Title: Energy-dense diets increase FGF23, lead to phosphorus retention and promote vascular calcifications in rats.
Authors: Raya, Ana I
Rios, Rafael
Pineda, Carmen
Rodriguez-Ortiz, Maria E
Diez, Elisa
Almaden, Yolanda
Muñoz-Castañeda, Juan R
Rodriguez, Mariano
Aguilera-Tejero, Escolastico
Lopez, Ignacio
metadata.dc.subject.mesh: Animals
Body Weight
Dietary Fats
Fibroblast Growth Factors
Gene Expression Regulation
Klotho Proteins
Vascular Calcification
Issue Date: 14-Nov-2016
Abstract: Rats with normal renal function (Experiment 1, n = 12) and uninephrectomized (1/2Nx) rats (Experiment 2, n = 12) were fed diets with normal P (NP) and either normal (NF) or high fat (HF). Rats with intact renal function (Experiment 3, n = 12) were also fed NF or HF diets with high P (HP). Additionally, uremic (5/6Nx) rats (n = 16) were fed HP diets with NF or HF. Feeding the HF diets resulted in significant elevation of plasma FGF23 vs rats fed NF diets: Experiment 1, 593 ± 126 vs 157 ± 28 pg/ml (p 
metadata.dc.identifier.doi: 10.1038/srep36881
Appears in Collections:Producción 2020

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