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Title: Ferroportin mRNA is down-regulated in granulosa and cervical cells from infertile women.
Authors: Moreno-Navarrete, José Maria
López-Navarro, Eva
Candenas, Luz
Pinto, Francisco
Ortega, Francisco J
Sabater-Masdeu, Mònica
Fernández-Sánchez, Manuel
Blasco, Victor
Romero-Ruiz, Antonio
Fontán, Marina
Ricart, Wifredo
Tena-Sempere, Manuel
Fernández-Real, José M
Keywords: Ferroportin;ferritin;infertility;in vitro fertilization;ovarian granulosa cells;sterility;uterine cervical cells
metadata.dc.subject.mesh: Adult
Antigens, CD
Case-Control Studies
Cation Transport Proteins
Cervical Atlas
Fertilization in Vitro
Granulosa Cells
RNA, Messenger
Receptors, Transferrin
Tertiary Care Centers
Young Adult
Issue Date: 16-Nov-2016
Abstract: To explore the relationship between iron and infertility by investigating iron-related gene expression in granulosa and uterine cervical cells. Case-control study. Two tertiary hospitals. Two independent cohorts of fertile (n = 18 and n = 17) and infertile (n = 31 and n = 35) women. In vitro fertilization. Gene expression levels of ferritin light chain (FTL), ferritin heavy chain (FTH), transferrin receptor (TFRC), and ferroportin (SLC40A1) mRNA were analyzed in granulosa and cervical cells. In the first cohort, fertile and infertile women were similar in body mass index. Ferroportin mRNA levels were decreased in granulosa cells from infertile women in parallel with increased serum hepcidin levels. A positive association between ferroportin and TFRC mRNA, a gene associated with intracellular iron deficiency, was observed only in granulosa cells from fertile women. The major findings were replicated in a second independent cohort. Ferroportin mRNAs and circulating hepcidin identify a subset of infertile women and may constitute a target for therapy.
metadata.dc.identifier.doi: 10.1016/j.fertnstert.2016.10.008
Appears in Collections:Producción 2020

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