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Title: SEOM Clinical Guideline of management of soft-tissue sarcoma (2016).
Authors: López-Pousa, A
Martin Broto, J
Martinez Trufero, J
Sevilla, I
Valverde, C
Alvarez, R
Carrasco Alvarez, J A
Cruz Jurado, J
Hindi, N
Garcia Del Muro, X
Keywords: Clinical guidelines;Sarcoma;Soft-tissue tumors;Uncommon tumors
metadata.dc.subject.mesh: Humans
Neoplasm Grading
Neoplasm Metastasis
Practice Guidelines as Topic
Soft Tissue Neoplasms
Issue Date: 2016
Abstract: Soft-tissue sarcomas are uncommon and heterogeneous tumors of mesenchymal origin. A soft-tissue mass that is increasing in size, greater than 5 cm, or located under deep fascia are criteria for suspicion of sarcoma. Diagnosis, treatment, and management should preferably be performed by a multidisciplinary team in reference centers. MRI and lung CT scan are mandatory for local and distant assessment. A biopsy indicating histological type and grade is needed previous to the treatment. Wide surgical resection with tumor-free tissue margin is the primary treatment for localized disease. Radiotherapy is indicated in large, deep, high-grade tumors, or after marginal resection not likely of being improved with reexcision. Neoadjuvant and adjuvant chemotherapy improve survival in selected cases, usually in high-grade sarcomas of the extremities. In the case of metastatic disease, patients with exclusive lung metastasis could be considered for surgery. First-line treatment with anthracyclines (or in combination with ifosfamide) is the treatment of choice. New drugs have shown activity in second-line therapy and in specific histological subtypes.
metadata.dc.identifier.doi: 10.1007/s12094-016-1574-1
Appears in Collections:Producción 2020

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