Publication: Lung Cancer in Women with a Family History of Cancer: The Spanish Female-specific Database WORLD07.
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2016
Authors
Isla, Dolores
Felip, Enriqueta
Viñolas, Nuria
Provencio, Mariano
Majem, Margarita
Artal, Angel
Bover, Isabel
Lianes, Pilar
DE Las Peñas, Ramón
Catot, Silvia
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Abstract
The WORLD07 project is a female-specific database to prospectively analyze the characteristics of Spanish women with lung cancer. We analyzed and compared lung cancer features in women with and without a family history of cancer/lung cancer. Two thousand and sixty women were included: 876 had a family history of cancer (lung cancer, 34%) and 886 did not, with no significant differences between groups, except for smoking status (p=0.036). We found statistically significant correlations between epidermal growth factor receptor (EGFR) mutation and smoking status in patients with a family history of cancer (r=-0.211; p Among Spanish women with lung cancer, a greater proportion were current smokers in those with a family history of cancer/lung cancer. There was a significant correlation between the presence of EGFR mutation and smoking.
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MeSH Terms
Carcinoma, Non-Small-Cell Lung
Carcinoma, Small Cell
ErbB Receptors
Female
Genetic Predisposition to Disease
Humans
Lung Neoplasms
Spain
Carcinoma, Small Cell
ErbB Receptors
Female
Genetic Predisposition to Disease
Humans
Lung Neoplasms
Spain
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Keywords
Cancer, Spanish women, WORLD07 database, epidermal growth factor receptor, family history, lung cancer risk, menopausal status, smoking