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Title: Salvage Therapy with Ceftolozane-Tazobactam for Multidrug-Resistant Pseudomonas aeruginosa Infections.
Authors: Castón, Juan José
De la Torre, Álvaro
Ruiz-Camps, Isabel
Sorlí, María Luisa
Torres, Vicente
Torre-Cisneros, Julián
Keywords: Pseudomonas aeruginosa;ceftolozane-tazobactam;salvage therapy
metadata.dc.subject.mesh: Adult
Anti-Bacterial Agents
Drug Resistance, Multiple, Bacterial
Microbial Sensitivity Tests
Middle Aged
Penicillanic Acid
Pneumonia, Bacterial
Pseudomonas Infections
Pseudomonas aeruginosa
Retrospective Studies
Salvage Therapy
Shock, Septic
Survival Analysis
Issue Date: 23-Feb-2017
Abstract: Infections caused by multidrug-resistant Pseudomonas aeruginosa (MDRPA) present a major problem for therapeutic management. We report here our experience with 12 patients with a severe MDRPA infection (6 of which were pneumonia) who received salvage therapy with ceftolozane-tazobactam after inappropriate empirical treatment and/or suboptimal targeted treatment. Although 10 of the 12 patients (83.3%) experienced septic shock, only 3 patients (25%) died during the follow-up period. Microbiological cure in 7 patients (58.3%) was observed.
metadata.dc.identifier.doi: 10.1128/AAC.02136-16
Appears in Collections:Producción 2020

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