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http://hdl.handle.net/10668/10710
Title: | Dietary flavonoid intake and colorectal cancer risk in the European prospective investigation into cancer and nutrition (EPIC) cohort. |
Authors: | Zamora-Ros, Raul Barupal, Dinesh K Rothwell, Joseph A Jenab, Mazda Fedirko, Veronika Romieu, Isabelle Aleksandrova, Krasimira Overvad, Kim Kyrø, Cecilie Tjønneland, Anne Affret, Aurélie His, Mathilde Boutron-Ruault, Marie-Christine Katzke, Verena Kühn, Tilman Boeing, Heiner Trichopoulou, Antonia Naska, Androniki Kritikou, Maria Saieva, Calogero Agnoli, Claudia Santucci de Magistris, Maria Tumino, Rosario Fasanelli, Francesca Weiderpass, Elisabete Skeie, Guri Merino, Susana Jakszyn, Paula Sánchez, Maria-José Dorronsoro, Miren Navarro, Carmen Ardanaz, Eva Sonestedt, Emily Ericson, Ulrika Maria Nilsson, Lena Bodén, Stina Bueno-de-Mesquita, H B As Peeters, Petra H Perez-Cornago, Aurora Wareham, Nicholas J Khaw, Kay-Thee Freisling, Heinz Cross, Amanda J Riboli, Elio Scalbert, Augustin |
Keywords: | EPIC;colorectal cancer;diet;flavonoids;prospective cohort |
metadata.dc.subject.mesh: | Adult Aged Cell Proliferation Colorectal Neoplasms Diet Dietary Supplements Europe Female Flavonoids Follow-Up Studies Humans Male Middle Aged Nutritional Status Prospective Studies Risk Factors Surveys and Questionnaires White People |
Issue Date: | 19-Jan-2017 |
Abstract: | Flavonoids have been shown to inhibit colon cancer cell proliferation in vitro and protect against colorectal carcinogenesis in animal models. However, epidemiological evidence on the potential role of flavonoid intake in colorectal cancer (CRC) development remains sparse and inconsistent. We evaluated the association between dietary intakes of total flavonoids and their subclasses and risk of development of CRC, within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. A cohort of 477,312 adult men and women were recruited in 10 European countries. At baseline, dietary intakes of total flavonoids and individual subclasses were estimated using centre-specific validated dietary questionnaires and composition data from the Phenol-Explorer database. During an average of 11 years of follow-up, 4,517 new cases of primary CRC were identified, of which 2,869 were colon (proximal = 1,298 and distal = 1,266) and 1,648 rectal tumours. No association was found between total flavonoid intake and the risk of overall CRC (HR for comparison of extreme quintiles 1.05, 95% CI 0.93-1.18; p-trend = 0.58) or any CRC subtype. No association was also observed with any intake of individual flavonoid subclasses. Similar results were observed for flavonoid intake expressed as glycosides or aglycone equivalents. Intake of total flavonoids and flavonoid subclasses, as estimated from dietary questionnaires, did not show any association with risk of CRC development. |
URI: | http://hdl.handle.net/10668/10710 |
metadata.dc.identifier.doi: | 10.1002/ijc.30582 |
Appears in Collections: | Producción 2020 |
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