Please use this identifier to cite or link to this item:
Title: Dietary flavonoid intake and colorectal cancer risk in the European prospective investigation into cancer and nutrition (EPIC) cohort.
Authors: Zamora-Ros, Raul
Barupal, Dinesh K
Rothwell, Joseph A
Jenab, Mazda
Fedirko, Veronika
Romieu, Isabelle
Aleksandrova, Krasimira
Overvad, Kim
Kyrø, Cecilie
Tjønneland, Anne
Affret, Aurélie
His, Mathilde
Boutron-Ruault, Marie-Christine
Katzke, Verena
Kühn, Tilman
Boeing, Heiner
Trichopoulou, Antonia
Naska, Androniki
Kritikou, Maria
Saieva, Calogero
Agnoli, Claudia
Santucci de Magistris, Maria
Tumino, Rosario
Fasanelli, Francesca
Weiderpass, Elisabete
Skeie, Guri
Merino, Susana
Jakszyn, Paula
Sánchez, Maria-José
Dorronsoro, Miren
Navarro, Carmen
Ardanaz, Eva
Sonestedt, Emily
Ericson, Ulrika
Maria Nilsson, Lena
Bodén, Stina
Bueno-de-Mesquita, H B As
Peeters, Petra H
Perez-Cornago, Aurora
Wareham, Nicholas J
Khaw, Kay-Thee
Freisling, Heinz
Cross, Amanda J
Riboli, Elio
Scalbert, Augustin
Keywords: EPIC;colorectal cancer;diet;flavonoids;prospective cohort
metadata.dc.subject.mesh: Adult
Cell Proliferation
Colorectal Neoplasms
Dietary Supplements
Follow-Up Studies
Middle Aged
Nutritional Status
Prospective Studies
Risk Factors
Surveys and Questionnaires
White People
Issue Date: 19-Jan-2017
Abstract: Flavonoids have been shown to inhibit colon cancer cell proliferation in vitro and protect against colorectal carcinogenesis in animal models. However, epidemiological evidence on the potential role of flavonoid intake in colorectal cancer (CRC) development remains sparse and inconsistent. We evaluated the association between dietary intakes of total flavonoids and their subclasses and risk of development of CRC, within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. A cohort of 477,312 adult men and women were recruited in 10 European countries. At baseline, dietary intakes of total flavonoids and individual subclasses were estimated using centre-specific validated dietary questionnaires and composition data from the Phenol-Explorer database. During an average of 11 years of follow-up, 4,517 new cases of primary CRC were identified, of which 2,869 were colon (proximal = 1,298 and distal = 1,266) and 1,648 rectal tumours. No association was found between total flavonoid intake and the risk of overall CRC (HR for comparison of extreme quintiles 1.05, 95% CI 0.93-1.18; p-trend = 0.58) or any CRC subtype. No association was also observed with any intake of individual flavonoid subclasses. Similar results were observed for flavonoid intake expressed as glycosides or aglycone equivalents. Intake of total flavonoids and flavonoid subclasses, as estimated from dietary questionnaires, did not show any association with risk of CRC development.
metadata.dc.identifier.doi: 10.1002/ijc.30582
Appears in Collections:Producción 2020

Files in This Item:
There are no files associated with this item.

This item is protected by original copyright

Except where otherwise noted, Items on the Andalusian Health Repository site are licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives License.