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Title: Clinical status, quality of life, and work productivity in Crohn's disease patients after one year of treatment with adalimumab.
Authors: Saro, Cristina
Ceballos, Daniel
Muñoz, Fernando
de la Coba, Cristóbal
Aguilar, María Dolores
Lázaro, Pablo
García-Sánchez, Valle
Hernández, Mariola
Barrio, Jesús
de Francisco, Ruth
Fernández, Luis I
Barreiro-de Acosta, Manuel
metadata.dc.subject.mesh: Adalimumab
Crohn Disease
Follow-Up Studies
Immunosuppressive Agents
Middle Aged
Prospective Studies
Quality of Life
Treatment Outcome
Young Adult
Issue Date: 2017
Abstract: Clinical trials have shown the efficacy of adalimumab in Crohn's disease, but the outcome in regular practice remains unknown. The aim of the study was to examine clinical status, quality of life, and work productivity of Crohn's disease patients receiving adalimumab for one year in the context of usual clinical practice. This was a prospective, observational study with a one-year follow-up. After baseline, Crohn's disease patients were evaluated at 1, 3, 6, 9, and 12 months after starting treatment with adalimumab. Outcome variables included: clinical status (measured with CDAI), quality of life (measured with EuroQoL-5D and IBDQ), and work productivity (measured with WPAI questionnaire). These outcome variables were compared using the Student's t test or Wilcoxon test for paired comparison data according to the data distribution. Statistical significance was set at two-sided p The sample was composed of 126 patients (age [mean] 39.1 ± [standard deviation] 13.8 years; 51% male). Significant changes were observed during the follow-up period: CDAI decreased from [median] 194 ([25-75 percentiles] 121-269) to 48.2 (10.1-122.0) (p In regular practice, adalimumab is clinically effective in the treatment of Crohn's disease patients and results in a significant improvement in quality of life and work productivity.
metadata.dc.identifier.doi: 10.17235/reed.2016.4600/2016
ISSN: 1130-0108
Appears in Collections:Producción 2020

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