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Title: Ciprofloxacin-Mediated Mutagenesis Is Suppressed by Subinhibitory Concentrations of Amikacin in Pseudomonas aeruginosa.
Authors: Valencia, Estela Ynés
Esposito, Fernanda
Spira, Beny
Blázquez, Jesús
Galhardo, Rodrigo S
Keywords: Pseudomonas aeruginosa;SOS response;ciprofloxacin;recA
metadata.dc.subject.mesh: Amikacin
Anti-Bacterial Agents
Disk Diffusion Antimicrobial Tests
Gene Expression
Genes, Reporter
Pseudomonas aeruginosa
Rec A Recombinases
SOS Response, Genetics
Issue Date: 23-Feb-2017
Abstract: Resistance to antibiotics is a global health problem. Activation of the SOS response, and the subsequent elevation in mutagenesis, contributes to the appearance of resistance mutations. Among currently used drugs, quinolones are the most potent inducers of the SOS response. In the present study, we show that amikacin inhibits ciprofloxacin-mediated SOS induction and mutagenesis in Pseudomonas aeruginosa.
metadata.dc.identifier.doi: 10.1128/AAC.02107-16
Appears in Collections:Producción 2020

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