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Title: Helicobacter pylori infection, chronic corpus atrophic gastritis and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort: A nested case-control study.
Authors: Huang, Jiaqi
Zagai, Ulrika
Hallmans, Göran
Nyrén, Olof
Engstrand, Lars
Stolzenberg-Solomon, Rachael
Duell, Eric J
Overvad, Kim
Katzke, Verena A
Kaaks, Rudolf
Jenab, Mazda
Park, Jin Young
Murillo, Raul
Trichopoulou, Antonia
Lagiou, Pagona
Bamia, Christina
Bradbury, Kathryn E
Riboli, Elio
Aune, Dagfinn
Tsilidis, Konstantinos K
Capellá, Gabriel
Agudo, Antonio
Krogh, Vittorio
Palli, Domenico
Panico, Salvatore
Weiderpass, Elisabete
Tjønneland, Anne
Olsen, Anja
Martínez, Begoña
Redondo-Sanchez, Daniel
Chirlaque, Maria-Dolores
Hm Peeters, Petra
Regnér, Sara
Lindkvist, Björn
Naccarati, Alessio
Ardanaz, Eva
Larrañaga, Nerea
Boutron-Ruault, Marie-Christine
Rebours, Vinciane
Barré, Amélie
Bueno-de-Mesquita, H B As
Ye, Weimin
Keywords: EPIC cohort;H. pylori infection;chronic corpus atrophic gastritis;nested case-control study;pancreatic cancer risk
metadata.dc.subject.mesh: Adult
Antigens, Bacterial
Bacterial Proteins
Case-Control Studies
Gastritis, Atrophic
Helicobacter Infections
Helicobacter pylori
Middle Aged
Nutritional Status
Pancreatic Neoplasms
Issue Date: 2017
Abstract: The association between H. pylori infection and pancreatic cancer risk remains controversial. We conducted a nested case-control study with 448 pancreatic cancer cases and their individually matched control subjects, based on the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, to determine whether there was an altered pancreatic cancer risk associated with H. pylori infection and chronic corpus atrophic gastritis. Conditional logistic regression models were applied to calculate odds ratios (ORs) and corresponding 95% confidence intervals (CIs), adjusted for matching factors and other potential confounders. Our results showed that pancreatic cancer risk was neither associated with H. pylori seropositivity (OR = 0.96; 95% CI: 0.70, 1.31) nor CagA seropositivity (OR = 1.07; 95% CI: 0.77, 1.48). We also did not find any excess risk among individuals seropositive for H. pylori but seronegative for CagA, compared with the group seronegative for both antibodies (OR = 0.94; 95% CI: 0.63, 1.38). However, we found that chronic corpus atrophic gastritis was non-significantly associated with an increased pancreatic cancer risk (OR = 1.35; 95% CI: 0.77, 2.37), and although based on small numbers, the excess risk was particularly marked among individuals seronegative for both H. pylori and CagA (OR = 5.66; 95% CI: 1.59, 20.19, p value for interaction 
metadata.dc.identifier.doi: 10.1002/ijc.30590
Appears in Collections:Producción 2020

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