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Title: Influence of coronary artery disease and subclinical atherosclerosis related polymorphisms on the risk of atherosclerosis in rheumatoid arthritis.
Authors: López-Mejías, Raquel
Corrales, Alfonso
Vicente, Esther
Robustillo-Villarino, Montserrat
González-Juanatey, Carlos
Llorca, Javier
Genre, Fernanda
Remuzgo-Martínez, Sara
Dierssen-Sotos, Trinidad
Miranda-Filloy, José A
Huaranga, Marco A Ramírez
Pina, Trinitario
Blanco, Ricardo
Alegre-Sancho, Juan J
Raya, Enrique
Mijares, Verónica
Ubilla, Begoña
Ferraz-Amaro, Iván
Gómez-Vaquero, Carmen
Balsa, Alejandro
López-Longo, Francisco J
Carreira, Patricia
González-Álvaro, Isidoro
Ocejo-Vinyals, J Gonzalo
Rodríguez-Rodríguez, Luis
Fernández-Gutiérrez, Benjamín
Castañeda, Santos
Martín, Javier
González-Gay, Miguel A
metadata.dc.subject.mesh: Arthritis, Rheumatoid
Coronary Artery Disease
Genetic Predisposition to Disease
Middle Aged
Polymorphism, Single Nucleotide
Risk Factors
Issue Date: 6-Jan-2017
Abstract: A genetic component influences the development of atherosclerosis in the general population and also in rheumatoid arthritis (RA). However, genetic polymorphisms associated with atherosclerosis in the general population are not always involved in the development of cardiovascular disease (CVD) in RA. Accordingly, a study in North-American RA patients did not show the association reported in the general population of coronary artery disease with a series of relevant polymorphisms (TCF21, LPA, HHIPL1, RASD1-PEMT, MRPS6, CYP17A1-CNNM2-NT5C2, SMG6-SRR, PHACTR1, WDR12 and COL4A1-COL4A2). In the present study, we assessed the potential association of these polymorphisms with CVD in Southern European RA patients. We also assessed if polymorphisms implicated in the increased risk of subclinical atherosclerosis in non-rheumatic Caucasians (ZHX2, PINX1, SLC17A4, LRIG1 and LDLR) may influence the risk for CVD in RA. 2,609 Spanish patients were genotyped by TaqMan assays. Subclinical atherosclerosis was determined in 1,258 of them by carotid ultrasonography (assessment of carotid intima media thickness and presence/absence of carotid plaques). No statistically significant differences were found when each polymorphism was assessed according to the presence/absence of cardiovascular events and subclinical atherosclerosis, after adjustment for potential confounder factors. Our results do not show an association between these 15 polymorphisms and atherosclerosis in RA.
metadata.dc.identifier.doi: 10.1038/srep40303
Appears in Collections:Producción 2020

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