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http://hdl.handle.net/10668/10757| Title: | Accuracy of competing-risks model in screening for pre-eclampsia by maternal factors and biomarkers at 11-13 weeks' gestation. |
| Authors: | O'Gorman, N Wright, D Poon, L C Rolnik, D L Syngelaki, A Wright, A Akolekar, R Cicero, S Janga, D Jani, J Molina, F S de Paco Matallana, C Papantoniou, N Persico, N Plasencia, W Singh, M Nicolaides, K H |
| Keywords: | Bayes' theorem;first-trimester screening;mean arterial pressure;placental growth factor;pre-eclampsia;pregnancy-associated plasma protein-A;pyramid of pregnancy care;survival model;uterine artery Doppler |
| metadata.dc.subject.mesh: | Adult Biomarkers Europe Female Gestational Age Humans Models, Theoretical Placenta Growth Factor Pre-Eclampsia Pregnancy Pregnancy Trimester, First Prenatal Diagnosis Prospective Studies Pulsatile Flow Risk Assessment Sensitivity and Specificity Uterine Artery |
| Issue Date: | 14-May-2017 |
| Abstract: | To examine the diagnostic accuracy of a previously developed model for prediction of pre-eclampsia (PE) by a combination of maternal factors and biomarkers at 11-13 weeks' gestation. This was a prospective first-trimester multicenter study of screening for PE in 8775 singleton pregnancies. A previously published algorithm was used for the calculation of patient-specific risk of PE in each individual. The detection rates (DRs) and false-positive rates (FPRs) for delivery with PE In the study population, 239 (2.7%) cases developed PE, of which 17 (0.2%), 59 (0.7%) and 180 (2.1%) developed PE Assessment of a combination of maternal factors and biomarkers at 11-13 weeks provides effective first-trimester screening for preterm PE. Copyright © 2017 ISUOG. Published by John Wiley & Sons Ltd. |
| URI: | http://hdl.handle.net/10668/10757 |
| metadata.dc.identifier.doi: | 10.1002/uog.17399 |
| Appears in Collections: | Producción 2020 |
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