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Title: Markers of endothelial damage in patients with chronic kidney disease on hemodialysis.
Authors: Carmona, Andrés
Agüera, Maria L
Luna-Ruiz, Carlos
Buendía, Paula
Calleros, Laura
García-Jerez, Andrea
Rodríguez-Puyol, Manuel
Arias, Manuel
Arias-Guillen, Marta
de Arriba, Gabriel
Ballarin, Jose
Bernis, Carmen
Fernández, Elvira
García-Rebollo, Sagrario
Mancha, Javier
Del Peso, Gloria
Pérez, Estefanía
Poch, Esteban
Portolés, Jose M
Rodríguez-Puyol, Diego
Sánchez-Villanueva, Rafael
Sarro, Felipe
Torres, Armando
Martín-Malo, Alejandro
Aljama, Pedro
Ramírez, Rafael
Carracedo, Julia
Keywords: cardiovascular disease;chronic kidney disease;diabetes mellitus;inflammation, hemodialysis;microvesicles
metadata.dc.subject.mesh: Aged
Case-Control Studies
Cell-Derived Microparticles
Diabetic Nephropathies
Disease Progression
Endothelial Cells
Inflammation Mediators
Kaplan-Meier Estimate
Middle Aged
Predictive Value of Tests
Renal Dialysis
Renal Insufficiency, Chronic
Time Factors
Treatment Outcome
Issue Date: 11-Jan-2017
Abstract: Patients with Stage 5 chronic kidney disease who are on hemodialysis (HD) remain in a chronic inflammatory state, characterized by the accumulation of uremic toxins that induce endothelial damage and cardiovascular disease (CVD). Our aim was to examine microvesicles (MVs), monocyte subpopulations, and angiopoietins (Ang) to identify prognostic markers in HD patients with or without diabetes mellitus (DM). A total of 160 prevalent HD patients from 10 centers across Spain were obtained from the Biobank of the Nephrology Renal Network (Madrid, Spain): 80 patients with DM and 80 patients without DM who were matched for clinical and demographic criteria. MVs from plasma and several monocyte subpopulations (CD142+/CD16+, CD14+/CD162+) were analyzed by flow cytometry, and the plasma concentrations of Ang1 and Ang2 were quantified by ELISA. Data on CVD were gathered over the 5.5 yr after these samples were obtained. MV level, monocyte subpopulations (CD14+/CD162+ and CD142+/CD16+), and Ang2-to-Ang1 ratios increased in HD patients with DM compared with non-DM patients. Moreover, MV level above the median (264 MVs/µl) was associated independently with greater mortality. MVs, monocyte subpopulations, and Ang2-to-Ang1 ratio can be used as predictors for CVD. In addition, MV level has a potential predictive value in the prevention of CVD in HD patients. These parameters undergo more extensive changes in patients with DM.
metadata.dc.identifier.doi: 10.1152/ajprenal.00013.2016
Appears in Collections:Producción 2020

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