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Title: Plasmidic qnr Genes Confer Clinical Resistance to Ciprofloxacin under Urinary Tract Physiological Conditions.
Authors: Martín-Gutiérrez, Guillermo
Rodríguez-Martínez, José Manuel
Pascual, Álvaro
Rodríguez-Beltrán, Jerónimo
Blázquez, Jesús
Keywords: Escherichia coli;MIC;ciprofloxacin;pH;qnr;urinary tract infection
metadata.dc.subject.mesh: Anti-Bacterial Agents
Drug Resistance, Bacterial
Escherichia coli
Microbial Sensitivity Tests
Urinary Tract Infections
Issue Date: 24-Mar-2017
Abstract: Escherichia coli variants expressing plasmid-mediated qnr genes are usually susceptible to fluoroquinolones by standard susceptibility testing. Here we show that, under specific urinary tract physiological conditions, susceptible laboratory and clinical strains harboring qnr determinants become fully resistant to ciprofloxacin (CIP). Therefore, physiological conditions, mainly urine pH values, should be considered when performing susceptibility testing of CIP activity against E. coli in treating urinary tract infection (UTI) and for selecting appropriate antibiotics for UTI treatment.
metadata.dc.identifier.doi: 10.1128/AAC.02615-16
Appears in Collections:Producción 2020

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