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http://hdl.handle.net/10668/10797| Title: | An inhibitory pull-push circuit in frontal cortex. |
| Authors: | Garcia-Junco-Clemente, Pablo Ikrar, Taruna Tring, Elaine Xu, Xiangmin Ringach, Dario L Trachtenberg, Joshua T |
| metadata.dc.subject.mesh: | Animals Arousal Channelrhodopsins Feedback, Physiological Female Frontal Lobe Interneurons Locomotion Male Mice Mice, Transgenic Neural Inhibition Pupil Pyramidal Cells Vasoactive Intestinal Peptide |
| Issue Date: | 23-Jan-2017 |
| Abstract: | Push-pull is a canonical computation of excitatory cortical circuits. By contrast, we identify a pull-push inhibitory circuit in frontal cortex that originates in vasoactive intestinal polypeptide (VIP)-expressing interneurons. During arousal, VIP cells rapidly and directly inhibit pyramidal neurons; VIP cells also indirectly excite these pyramidal neurons via parallel disinhibition. Thus, arousal exerts a feedback pull-push influence on excitatory neurons-an inversion of the canonical push-pull of feedforward input. |
| URI: | http://hdl.handle.net/10668/10797 |
| metadata.dc.identifier.doi: | 10.1038/nn.4483 |
| Appears in Collections: | Producción 2020 |
Files in This Item:
| File | Size | Format | |
|---|---|---|---|
| PMC5967235.pdf | 1,31 MB | Adobe PDF | View/Open |
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