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Title: Relationship between drugs affecting the renin-angiotensin system and colorectal cancer: The MCC-Spain study.
Authors: Dierssen-Sotos, Trinidad
Gómez-Acebo, Inés
Palazuelos, Camilo
Rodriguez-Moranta, Francisco
Pérez-Gómez, Beatriz
Fernández Vazquez, José Pedro
Amiano, Pilar
Barricarte, Aurelio
Mirón-Pozo, Benito
Tardon, Adonina
Capelo, Rocío
Peiro Pérez, Rosana
Huerta, José María
Andreu, Montserrat
Sierra, Mª Ángeles
Castañón López, Carmen
Ruiz, Irune
Moreno-Iribas, Concepción
Olmedo-Requena, Rocío
Castaño-Vinyals, Gemma
Aragonés, Nuria
Kogevinas, Manolis
Pollán, Marina
Llorca, Javier
Keywords: Angiotensin converting enzyme inhibitor;Angiotensin receptor blocker;Colorectal cancer
metadata.dc.subject.mesh: Age Factors
Angiotensin Receptor Antagonists
Angiotensin-Converting Enzyme Inhibitors
Case-Control Studies
Colorectal Neoplasms
Middle Aged
Renin-Angiotensin System
Sex Factors
Issue Date: 26-Jan-2017
Abstract: The potential protective effect of renin-angiotensin system (RAS) inhibitors is a subject of increasing interest due to their possible role as chemopreventive agents against colorectal cancer (CRC). To evaluate this association, we conducted a case-control study with 2165 cases of colorectal cancer, diagnosed between 2007 and 2012, and 3912 population controls frequency matched (by age, sex and region) from the Spanish multicenter case-control study MCC-Spain. We found a significant protective effect of the angiotensin-converting enzyme Inhibitors (ACEIs) against CRC, limited to the under-65years group (OR=0.65 95%CI (0.48-0.89)) and to a lesser degree to men (OR=0.81 95%CI (0.66-0.99). In contrast, the angiotensin receptor blockers (ARBs) did not show a significant effect. Regarding the duration of use, a greater protection was observed in men as the length of consumption increases. In contrast, in the under-65 stratum, the strongest association was found in short-term treatments. Finally, by analyzing ACEIs effect by colon subsite, we found no differences, except for under 65years old, where the maximum protection was seen in the proximal intestine, descending in the distal and rectum (without statistical significance). In conclusion, our study shows a protective effect on CRC of the ACEis limited to males and people under 65years old, which increases in proximal colon in the latter. If confirmed, these results may suggest a novel approach to proximal CRC prevention, given the shortcomings of colonoscopy screening in this location.
metadata.dc.identifier.doi: 10.1016/j.ypmed.2017.01.011
Appears in Collections:Producción 2020

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