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http://hdl.handle.net/10668/10849| Title: | Branimycins B and C, Antibiotics Produced by the Abyssal Actinobacterium Pseudonocardia carboxydivorans M-227. |
| Authors: | Braña, Alfredo F Sarmiento-Vizcaíno, Aida Pérez-Victoria, Ignacio Otero, Luis Fernández, Jonathan Palacios, Juan José Martín, Jesús de la Cruz, Mercedes Díaz, Caridad Vicente, Francisca Reyes, Fernando García, Luis A Blanco, Gloria |
| metadata.dc.subject.mesh: | Anti-Bacterial Agents Enterococcus faecalis Gram-Negative Bacteria Gram-Positive Bacteria Haemophilus influenzae Macrolides Methicillin-Resistant Staphylococcus aureus Microbial Sensitivity Tests Molecular Structure Nuclear Magnetic Resonance, Biomolecular |
| Issue Date: | 7-Feb-2017 |
| Abstract: | Two new antibiotics, branimycins B (2) and C (3), were produced by fermentation of the abyssal actinobacterium Pseudonocardia carboxydivorans M-227, isolated from deep seawater of the Avilés submarine Canyon. Their structures were elucidated by HRMS and NMR analyses. These compounds exhibit antibacterial activities against a panel of Gram-positive bacteria, including Corynebacterium urealyticum, Clostridium perfringens, and Micrococcus luteus, and against the Gram-negative bacterium Neisseria meningitidis. Additionally, branimycin B displayed moderate antibacterial activity against other Gram-negative bacteria such as Bacteroides fragilis, Haemophilus influenzae, and Escherichia coli, and branimycin C against the Gram-positive Enterococcus faecalis and methicillin-sensitive and methicillin-resistant Staphylococcus aureus. |
| URI: | http://hdl.handle.net/10668/10849 |
| metadata.dc.identifier.doi: | 10.1021/acs.jnatprod.6b01107 |
| Appears in Collections: | Producción 2020 |
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