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Title: Branimycins B and C, Antibiotics Produced by the Abyssal Actinobacterium Pseudonocardia carboxydivorans M-227.
Authors: Braña, Alfredo F
Sarmiento-Vizcaíno, Aida
Pérez-Victoria, Ignacio
Otero, Luis
Fernández, Jonathan
Palacios, Juan José
Martín, Jesús
de la Cruz, Mercedes
Díaz, Caridad
Vicente, Francisca
Reyes, Fernando
García, Luis A
Blanco, Gloria
metadata.dc.subject.mesh: Anti-Bacterial Agents
Enterococcus faecalis
Gram-Negative Bacteria
Gram-Positive Bacteria
Haemophilus influenzae
Methicillin-Resistant Staphylococcus aureus
Microbial Sensitivity Tests
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Issue Date: 7-Feb-2017
Abstract: Two new antibiotics, branimycins B (2) and C (3), were produced by fermentation of the abyssal actinobacterium Pseudonocardia carboxydivorans M-227, isolated from deep seawater of the Avilés submarine Canyon. Their structures were elucidated by HRMS and NMR analyses. These compounds exhibit antibacterial activities against a panel of Gram-positive bacteria, including Corynebacterium urealyticum, Clostridium perfringens, and Micrococcus luteus, and against the Gram-negative bacterium Neisseria meningitidis. Additionally, branimycin B displayed moderate antibacterial activity against other Gram-negative bacteria such as Bacteroides fragilis, Haemophilus influenzae, and Escherichia coli, and branimycin C against the Gram-positive Enterococcus faecalis and methicillin-sensitive and methicillin-resistant Staphylococcus aureus.
metadata.dc.identifier.doi: 10.1021/acs.jnatprod.6b01107
Appears in Collections:Producción 2020

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