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Title: The neuropeptides Galanin and Galanin(1-15) in depression-like behaviours.
Authors: Millón, Carmelo
Flores-Burgess, Antonio
Narváez, Manuel
Borroto-Escuela, Dasiel O
Gago, Belén
Santín, Luis
Castilla-Ortega, Estela
Narváez, José Ángel
Fuxe, Kjell
Díaz-Cabiale, Zaida
Keywords: Depression;Galanin
metadata.dc.subject.mesh: Animals
Central Nervous System
Depressive Disorder
Receptors, Galanin
Issue Date: 31-Jan-2017
Abstract: Galanin is a 29 amino acid neuropeptide widely distributed in neurons within the central nervous system. Galanin exerts its biological activities through three different G protein-receptors and participates in a number of functions, including mood regulation. Not only Galanin but also Galanin N-terminal fragments like Galanin(1-15) are active at the central level. In this work, we review the latest findings in studies on Galanin and Galanin(1-15) in depression-related behaviours. Our focus is on animal models for depression, and we pay some attention to research data obtained in human studies. Since Serotonin (5-HT), especially through 5-HT1A, and Galanin receptors interact at both pre-and postsynaptic level, the development of drugs targeting potential GAL1-GAL2-5-HT1A heteroreceptor complexes linked to the raphe-hippocampal 5-HT neurons may represent new treatment strategies in depression.
metadata.dc.identifier.doi: 10.1016/j.npep.2017.01.004
Appears in Collections:Producción 2020

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