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Title: Total and subtypes of dietary fat intake and risk of type 2 diabetes mellitus in the Prevención con Dieta Mediterránea (PREDIMED) study.
Authors: Guasch-Ferré, Marta
Becerra-Tomás, Nerea
Ruiz-Canela, Miguel
Corella, Dolores
Schröder, Helmut
Estruch, Ramon
Ros, Emilio
Arós, Fernando
Gómez-Gracia, Enrique
Fiol, Miquel
Serra-Majem, Lluís
Lapetra, José
Basora, Josep
Martín-Calvo, Nerea
Portoles, Olga
Fitó, Montserrat
Hu, Frank B
Forga, Lluís
Salas-Salvadó, Jordi
Keywords: PREDIMED study;dietary fat;fat subtypes;monounsaturated fat;saturated fat;type 2 diabetes;ω-3 fatty acids
metadata.dc.subject.mesh: Aged
Cardiovascular Diseases
Diabetes Mellitus, Type 2
Diet, Mediterranean
Dietary Fats
Fatty Acids
Feeding Behavior
Follow-Up Studies
Middle Aged
Proportional Hazards Models
Prospective Studies
Risk Factors
Issue Date: 15-Feb-2017
Abstract: Background: The associations between dietary fat and cardiovascular disease have been evaluated in several studies, but less is known about their influence on the risk of diabetes.Objective: We examined the associations between total fat, subtypes of dietary fat, and food sources rich in saturated fatty acids and the incidence of type 2 diabetes (T2D).Design: A prospective cohort analysis of 3349 individuals who were free of diabetes at baseline but were at high cardiovascular risk from the PREvención con DIeta MEDiterránea (PREDIMED) study was conducted. Detailed dietary information was assessed at baseline and yearly during the follow-up using a food frequency questionnaire. Multivariable Cox proportional hazards models were used to estimate T2D HRs and 95% CIs according to baseline and yearly updated fat intake.Results: We documented 266 incident cases during 4.3 y of follow-up. Baseline saturated and animal fat intake was not associated with the risk of T2D. After multivariable adjustment, participants in the highest quartile of updated intake of saturated and animal fat had a higher risk of diabetes than the lowest quartile (HR: 2.19; 95% CI: 1.28, 3.73; and P-trend = 0.01 compared with HR: 2.00; 95% CI: 1.29, 3.09; and P-trend
metadata.dc.identifier.doi: 10.3945/ajcn.116.142034
Appears in Collections:Producción 2020

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